March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Long-term Observation Of Choroidal Thickness In Vogt-koyanagi-harada Disease
Author Affiliations & Notes
  • Kouhei Hashizume
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Yutaka Imamura
    Ophthalmology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan
  • Takamitsu Fujiwara
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Shigeki Machida
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Masahiro Ishida
    Ophthalmology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan
  • Daijiro Kurosaka
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Footnotes
    Commercial Relationships  Kouhei Hashizume, None; Yutaka Imamura, None; Takamitsu Fujiwara, None; Shigeki Machida, None; Masahiro Ishida, None; Daijiro Kurosaka, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3203. doi:https://doi.org/
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      Kouhei Hashizume, Yutaka Imamura, Takamitsu Fujiwara, Shigeki Machida, Masahiro Ishida, Daijiro Kurosaka; Long-term Observation Of Choroidal Thickness In Vogt-koyanagi-harada Disease. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3203. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To investigate the change of choroidal thickness during the follow-up of Vogt-Koyanagi-Harada disease (VKH) after high-dose steroid therapy.

 
Methods:
 

Subfoveal choroidal thicknesses in eyes with VKH were measured before high-dose steroid therapy and monitored during the follow-up using enhanced depth imaging optical coherence tomography.

 
Results:
 

Seventeen patients with acute stage of VKH (11 females, mean age: 52 years) were enrolled in this study and all eyes showed retinal detachment. The patients were treated with intravenous high-dose steroid and subsequently with oral administration of steroid. The mean choroidal thickness before high-dose steroid was 889 ± 183 (mean ± SD) μm, which continued decreasing to the thickness of 314 ± 111μm at 3-month follow-up (Student t test, P < 0.001). The mean choroidal thickness at 1-year follow-up was 310 ± 78 μm (P < 0.001).

 
Conclusions:
 

Choroid is remarkably thick in eyes with acute VKH and continues shrinking at least for 3 months after high-dose steroid therapy. Choroidal inflammation in VKH appears to persist for a longer period than previously thought.  

 
Keywords: uveitis-clinical/animal model • choroid • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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