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Mark Gold, Seema Kansara, Nicholas Bell, Alice Chuang, Laura Baker, Robert Feldman; Age Related Changes in Trabecular Meshwork. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3242.
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To evaluate the effect of age on trabecular meshwork (TM) cross sectional area, size and length, by analyzing the Anterior Segment Optical Coherence Tomography (ASOCT) images of normal subjects.
Fifteen subjects with gonioscopically open angles were selected from each age group (18-40, 41-60, 61-80) from the Cizik Eye Clinic, UTHealth. One eye was randomly selected to be imaged by anterior segment optical coherence tomography (ASOCT, Casia SS-1000, Tomey, Japan) using 2D mode and anterior segment scan type. Two independent readers measured the area and the length of TM at the temporal angles using proprietary software (Acai, Houston, Texas). The TM interface shadow (a hyporeflective band which wraps tightly around the TM) was also measured. Interobserver reproducibility was evaluated using an intraclass correlation coefficient (ICC) in a mixed model. To evaluate the effect of age on TM, the average TM parameters obtained from 2 readers and adjusted for sex, race, IOP, and gonioscopy score (≤3 vs 4) were evaluated using stepwise regression analysis.
In summary, the TM interface shadow area was found to increase with age. Further study is required to determine whether there is any relationship between TM interface shadow area and disease processes.
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