March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Changes In Anterior Segment And Angle Configuration Over Four Years In A Cohort Of Singaporean Subjects With Open Angles
Author Affiliations & Notes
  • Yingke He
    Duke-NUS Graduate Medical School, Singapore, Singapore
  • Mani Baskaran
    Glaucoma,
    Singapore Eye Research Institute, Singapore, Singapore
  • Tin A. Tun
    Clinic,
    Singapore Eye Research Institute, Singapore, Singapore
  • Arun K. Narayanaswamy
    Glaucoma,
    Singapore Eye Research Institute, Singapore, Singapore
  • Tin Aung
    Glaucoma, Singapore National Eye Center, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Yingke He, None; Mani Baskaran, None; Tin A. Tun, None; Arun K. Narayanaswamy, None; Tin Aung, Carl Zeiss Meditec, Dublin, CA (R)
  • Footnotes
    Support  Singhealth Grant
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3265. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yingke He, Mani Baskaran, Tin A. Tun, Arun K. Narayanaswamy, Tin Aung; Changes In Anterior Segment And Angle Configuration Over Four Years In A Cohort Of Singaporean Subjects With Open Angles. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3265.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To prospectively assess changes in angle configuration and anterior segment parameters measured by anterior segment optical coherence tomography (Visante ASOCT, Carl Zeiss Meditec, Dublin, CA) over four years in a cohort of Singaporean subjects with open angles.

 
Methods:
 

339 open angle subjects aged >50 without ophthalmic symptoms were recruited from a community-based clinic. All subjects underwent gonioscopy and ASOCT imaging at baseline and four years later. Gonioscopic angle closure was defined as the presence of Shaffers’ grading ≤1 for three or more quadrants. Horizontal ASOCT images were analyzed for the following measurements: angle opening distance (AOD) at 750μm from the scleral spur; trabecular-iris space area (TISA) at 750μm; iris area (IAREA), iris thickness (IT) at 2000μm, iris curvature (ICURV), anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV) and lens vault (LV).

 
Results:
 

Of the 339 subjects, 204 subjects (61%) had high quality ASOCT images at baseline and at Year 4. The mean age of study subjects at follow up was 63.9(SD 6.4) years; 53.7% were female and 86% were Chinese. Overall, from baseline to Year 4, there was decrease in mean Shaffer grade, ACD, AOD750, TISA750, IT2000, and IAREA in both nasal and temporal quadrants (p<0.05). There was an increase in ICURV (in the temporal quadrant) as well as LV compared to baseline (p<0.05). 19 out of 204 patients (9%) were found to have developed gonioscopic angle closure at the 4-year follow-up visit. Subjects who developed angle closure had lower mean Shaffer grade, ACD, AOD750, TISA750, ACA and ACV but higher LV and temporal ICURV (all p<0.05) at baseline, compared to those whose angles remained open.

 
Conclusions:
 

In this cohort of open angle subjects followed-up over four years with ASOCT, there was a significant decrease in angle width, iris area and thickness, but increase in temporal iris curvature and lens vault. Almost 10% of subjects developed gonioscopic angle closure over this period; those who developed angle closure had smaller angle and anterior segment measurements but thicker LV at baseline.  

 
Keywords: anterior segment • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×