March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
No Association between Genotypes in Glutathione S-transferase and Age-related Macular Degeneration
Author Affiliations & Notes
  • Yara T. Lechanteur
    Ophthalmology,
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Wilbert H. Peters
    Gastroenterology,
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Rene H. te Morsche
    Gastroenterology,
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Sascha Fauser
    Vitreoretinal Surgery, University Eye Hospital Cologne, Cologne, Germany
  • Anneke I. Den Hollander
    Ophthalmology,
    Human Genetics,
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Carel C. Hoyng
    Ophthalmology,
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Footnotes
    Commercial Relationships  Yara T. Lechanteur, None; Wilbert H. Peters, None; Rene H. te Morsche, None; Sascha Fauser, None; Anneke I. Den Hollander, None; Carel C. Hoyng, None
  • Footnotes
    Support  Stichting MD fonds
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3307. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yara T. Lechanteur, Wilbert H. Peters, Rene H. te Morsche, Sascha Fauser, Anneke I. Den Hollander, Carel C. Hoyng; No Association between Genotypes in Glutathione S-transferase and Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3307.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Oxidative stress plays a major role in the development of age-related macular degeneration (AMD). In a previous study an association was described between polymorphisms in genes encoding components of the glutathione S-transferase (GST) antioxidant system and the development of AMD. However, the sample size in that study was very small (35 patients and 159 control subjects). This study was conducted to investigate these relations in a larger cohort.

Methods: : DNA samples of 760 AMD patients and 576 race-matched controls from the EUGENDA database were genotyped for deletion polymorphisms in GSTM1 and GSTT1 that result in no activity of the corresponding enzymes, and a functional polymorphism in GSTP1 (p.Ile105Val) that lowers the enzyme activity. The Chi-square test was used to determine whether the genotype frequencies in patients differ from those in controls.

Results: : No direct associations were observed between the GSTM1, GSTT1 or GSTP1 genotypes and AMD. Also, combined genotype analyses did not reveal any associations. Results did not change after correction for sex, age and smoking status in logistic regression analysis.

Conclusions: : Our results are in contrast with the results of a previously reported study, since we could not confirm the observed associations using a large AMD cohort. Our data strongly indicate that the GSTM1, GSTT1 and GSTP1 genotypes do not confer a risk on the development of AMD.

Keywords: age-related macular degeneration • genetics • clinical (human) or epidemiologic studies: risk factor assessment 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×