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Han Jin Oh, Jae Yong Jang, Zhengri Li, In Cheon You, Kyung Chul Yoon; Effects of Umbilical Cord Serum Eye-drops in a Mouse Model of Ocular Chemical Burn. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3535.
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To evaluate the effect of umbilical cord serum eye-drops on corneal wound healing and haze in a mouse model of ocular chemical burn and compare with that of peripheral blood serum eye-drops or artificial tears.
Chemical burn of the ocular surface was induced by 1N NaOH in C57BL/6 mice. The mice were topically treated with 20% umbilical cord serum eye-drops (group A), 20% peripheral blood serum eye-drops (group B), or artificial tears (group C) four times daily. Degrees of corneal epithelial defects and haze were analyzed at 6 hour, 1, 2, 3, 5, and 7 days, and histologic examination was performed at 3 and 7 days after inducing chemical burn.
Group A and B showed lower epithelial defect parameters and haze scores from 2 days compared with group C (P<0.05). There were no significant differences in epithelial defect areas between group A and B. Corneal haze scores at 2 and 7 days were 2.14 ± 0.77 and 1.07 ± 0.99 in group A, and 3.07 ± 0.73 and 1.86 ± 0.86 in group B (P<0.05), respectively. Histologic examination showed better epithelial integrity and lower stromal inflammation and edema in group A than other groups.
Umbilical cord serum eye-drops were more effective in improving corneal wound healing compared with artificial tears and reducing corneal haze compared with peripheral blood serum eye-drops in experimentally induced ocular chemical burn.
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