March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Spectral Domain Optical Coherence Tomography (SDOCT) detects lamina cribrosa hypercompliance in Non-human Primate (NHP) early experimental glaucoma (EEG)
Author Affiliations & Notes
  • Galen Williams
    Devers Eye Institute, Legacy Health System, Portland, Oregon
  • Hongli Yang
    Optic Nerve Head Research Lab,
    Devers Eye Institute, Portland, Oregon
  • Ziyang Liu
    Devers Eye Institute, Legacy Health System, Portland, Oregon
  • Stuart K. Gardiner
    Discoveries In Sight Laboratories,
    Devers Eye Institute, Portland, Oregon
  • Christy A. Hardin
    Optic Nerve Head Rsch Lab,
    Devers Eye Institute, Portland, Oregon
  • J Crawford C. Downs
    Ocular Biomechanics Laboratory,
    Devers Eye Institute, Portland, Oregon
  • Brad Fortune
    Devers Eye Institute, Legacy Health, Portland, Oregon
  • Claude F. Burgoyne
    Optic Nerve Head Research Lab,
    Devers Eye Institute, Portland, Oregon
  • Footnotes
    Commercial Relationships  Galen Williams, None; Hongli Yang, None; Ziyang Liu, None; Stuart K. Gardiner, None; Christy A. Hardin, None; J Crawford C. Downs, None; Brad Fortune, Equipment from Carl Zeiss Meditech Inc. and Heidelberg Engineering. (F); Claude F. Burgoyne, equipment and unrestricted research support from Heidelberg Engineering, GmbH. (F)
  • Footnotes
    Support  NIH/NEI R01-EY021281;NIH/NEI R01-EY-019674
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3692. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Galen Williams, Hongli Yang, Ziyang Liu, Stuart K. Gardiner, Christy A. Hardin, J Crawford C. Downs, Brad Fortune, Claude F. Burgoyne; Spectral Domain Optical Coherence Tomography (SDOCT) detects lamina cribrosa hypercompliance in Non-human Primate (NHP) early experimental glaucoma (EEG). Invest. Ophthalmol. Vis. Sci. 2012;53(14):3692.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To compare acute SDOCT IOP 10/30 optic nerve head (ONH) parameter change (SDOCT compliance) within the normal (N) and EEG eyes of NHPs at the onset of unilateral EEG.

 
Methods:
 

In both eyes of 9 rhesus NHPs (5-22 y.o.) SDOCT and Confocal Scanning Laser Tomography (CSLT) (both Heidelberg Engineering) ONH imaging was performed 30 minutes after manometric IOP lowering to 10 mm Hg and again 30 minutes after elevation to 30 mm prior to and every two weeks following the onset of unilateral laser-induced chronic IOP elevation. EEG was defined as the onset of CSLT surface change confirmed on two occasions. Within the 40 radial B-scans of the 30º SD-OCT volumes from the second EEG confirmation session, masked operators delineated the retinal and ONH landmarks necessary to quantify: anterior lamina cribrosa surface depth (ALCSD) relative to a Bruch’s Membrane Opening (BMO) reference plane (ALCSD-BMO, see Figure), ALCSD relative to a peripheral BM reference plane (ALCSD-BM), neuroretinal rim width and BMO depth relative to the same peripheral BM reference plane (BMODepth). Random effects models assessed the relative effects of acute IOP elevation, N vs EEG eye status and the interactions between the two on each parameter.

 
Results:
 

ALCSD-BMO change due to acute IOP elevation was significantly greater in the EEG (50±40 μm (mean±s.d.)) compared to normal (10±16 μm) eyes (p=0.0009). ALCSD-BM change due to IOP was greater in EEG (80±66 μm) compared to normal (40±27 μm) eyes (p=0.07). Significant compliance was observed for all eyes between IOP 10 and 30 for BMO depth (p<0.0001) and rim width (p<0.0001) , but no significant difference in compliance was observed between N and EEG eyes for these two parameters.

 
Conclusions:
 

In a pooled analysis, NHP EEG eyes cross-sectionally exhibit significantly more SDOCT lamina cribrosa compliance than their contralateral normal eyes as measured by ALCSD-BMO. This finding appears to be eye-specific and may be a manifestation of EEG-induced alterations in lamina cribrosa and peripapillary scleral structural stiffness.  

 
Keywords: optic nerve • lamina cribrosa • imaging/image analysis: non-clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×