March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Improved Reproducibility of SD-OCT Laminar Cribrosa Thickness Measurement Using Maximum Intensity Projection Image
Author Affiliations & Notes
  • Tae-Woo Kim
    Ophthalmology, Seoul National Univ Bundang Hosp, Seongnam, Republic of Korea
  • Eun Ji Lee
    Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Robert Weinreb
    Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Center, University of California San Diego, La Jolla, California
  • Footnotes
    Commercial Relationships  Tae-Woo Kim, None; Eun Ji Lee, None; Robert Weinreb, Heidelberg (C)
  • Footnotes
    Support  National Research Foundation of Korea Grant funded by Korean Government (2010-0004210).
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3696. doi:
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      Tae-Woo Kim, Eun Ji Lee, Robert Weinreb; Improved Reproducibility of SD-OCT Laminar Cribrosa Thickness Measurement Using Maximum Intensity Projection Image. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3696.

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      © ARVO (1962-2015); The Authors (2016-present)

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The maximum intensity projection (MIP) allows the visualization of the highest or lowest intensity in a data volume along the current line of sight. The purpose of this study is to present the 3D MIP image of the optic nerve head (ONH) derived from spectral domain optical coherence tomography (SD-OCT) images, and to compare the reproducibility of measuring lamina cribrosa thickness (LCT) using MIP and standard B-scan images.


Optic discs of 20 healthy subjects, 20 glaucoma suspects and 30 glaucoma patients were scanned using enhanced depth imaging SD-OCT. The B-scan images were reconstructed 3 dimensionally using MIP. The LCT was measured in the thin volumetric section images generated by MIP as well as in the corresponding B-scan images. The LCT was defined as the distance between the level of anterior and the posterior borders of the lamina cribrosa.


The mean mid-horizontal LCT was 231.43 ± 41.38 μm in MIP volume images and 233.25 ± 43.18 μm in B-scan images. In general, the borders of the lamina cribrosa were more clearly visible using MIP images. The intraobserver and interobserver ICC were 0.940 and 0.875 for MIP images and 0.858 and 0.831 for B-scan images, respectively.


Thin volume section images generated by MIP had higher reproducibility in measuring LCT than the standard B-scan images. Using those images, the detection of the LC borders was more straightforward. This technique should facilitate the research involving the measurement of LCT.  

Keywords: lamina cribrosa • image processing 

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