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Honey H. Herce, Angela Jiang, Jillian Wang, Sashwati Roy, John Christoforidis; An Epidemiologic Study of Non-ocular Surgical Wound Healing Outcomes in Exudative Macular Degeneration Patients Receiving Intravitreal VEGF Inhibitors. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3803.
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To provide an institution-specific data regarding the percentage of non-ocular surgical procedures and the presence of surgical complications in patients with exudative AMD treated with intravitreal anti-VEGF agents and to compare these with AMD patients who did not receive intravitreal anti-VEGF therapy.
Retrospective, single center chart review of patients with exudative AMD at The Ohio State University Medical Center from January 1, 2000 to March 20, 2011. Data was collected from procedures performed ranging from minor to major surgical procedures. The data included patient demographics, medical and surgical history, post-operative data including Intensive Care (ICU) hospitalization, superficial and deep wound infections and wound dehiscence and treatment with intravitreal anti-VEGF injections. De-identified data was compiled and analyzed using unpaired t-test analysis.
The percentage of surgical procedures in the AMD population was found to be 50.5% (101/200) (Mean 7.1 +/- 9.4). Among those who have had any surgeries (N=101), there is not a significant difference in the mean number of surgeries between patients with no injections 62/101 (mean 5.96 +/- 6.63) and patients with injections 39/101 (mean 8.87 +/- 12.52) (p = 0.91). The incidence of wound infection without injection and with injection respectively was: ICU 5/62(8.06%) vs 1/39 (2.56%) (p = 0.40), superficial wound infection 2/62(3.23%) vs 1/39(2.56%) (p = 0.99) and there were no associated deep wound infections or wound dehiscence found in either population.
This study demonstrates a high percentage of patients with wet AMD that underwent surgical procedures. The incidence of wound infection did not differ significantly between the treated and not treated groups. Further investigation with a larger number of patients is warranted.
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