March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Peripheral Neuropathy Is Associated With Age-related Macular Degeneration In Diabetes
Author Affiliations & Notes
  • Xinyi Su
    Ophthalmology, National University Singapore, Singapore, Singapore
  • Carol Y. Cheung
    Level 5, SNEC Building,
    Singapore Eye Research Institute, Singapore, Singapore
  • Wan T. Tay
    Singapore Eye Research Institute, Singapore, Singapore
  • Tien Yin Wong
    Ophthalmology, National University Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Xinyi Su, None; Carol Y. Cheung, None; Wan T. Tay, None; Tien Yin Wong, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3810. doi:
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      Xinyi Su, Carol Y. Cheung, Wan T. Tay, Tien Yin Wong; Peripheral Neuropathy Is Associated With Age-related Macular Degeneration In Diabetes. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3810.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Age-related macular degeneration (AMD) is the leading cause of blindness in Western countries. Increasing age, current cigarette smoking, previous cataract surgery, and a family history of AMD are strong risk factors associated with late AMD. Cardiovascular risk factors such as hypertension, higher body mass index, cholesterol levels and diabetes show a much weaker association with AMD. In this study , we aim to examine the association between diabetic peripheral neuropathy with age-related macular degeneration in a multi-ethnic Asian population

Methods: : Population-based, cross-sectional study of 413 diabetic subjects of Chinese, Malay and Indian ethnicity aged 24 to 95 years were included. Diabetes was defined as fasting plasma glucose ≥7 mmol/L (≥ 126 mg/dL) or self-reported physician-diagnosed diabetes or use of glucose-lowering medication. AMD was graded from retinal photographs according to the Wisconsin Age-Related Maculopathy Grading System. Peripheral neuropathy was defined from neurothesiometer or monofilament sensory testing. Data on major cardiovascular risk factors and blood pressure were collected.

Results: : 33 (8% of 413 diabetic subjects) subjects were identified to have AMD. After controlling for age, gender and race, diabetic patients with PN were more likely to develop AMD (odds ratio 2.495, 95% CI: 1.049 - 5.936) as compared with the diabetic subjects without PN. This association remains consistent (odds ratio 2.675, 95% CI: 1.097 - 6.520) after further controlling for smoking, total cholesterol and central retinal venular equivalent (CRVE).

Conclusions: : Diabetic patients with PN are more likely to have AMD, after controlling for known AMD risk factors including smoking. Our study suggests that PN in diabetes may be a risk factor of AMD.

Keywords: age-related macular degeneration • diabetes 

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