March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Plasma omega3 fatty acids and the risk for age-related macular degeneration: the Alienor Study
Author Affiliations & Notes
  • Benedicte Merle
    INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
  • Marie-Noëlle Delyfer
    INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Service d’Ophtalmologie, CHU de Bordeaux, F-33000, Bordeaux, France
  • Jean-François Korobelnik
    INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Service d’Ophtalmologie, CHU de Bordeaux, F-33000, Bordeaux, France
  • Marie-Bénédicte Rougier
    Service d’Ophtalmologie, CHU de Bordeaux, F-33000, Bordeaux, France
  • Florence Malet
    Service d’Ophtalmologie, CHU de Bordeaux, F-33000, Bordeaux, France
  • Mélanie Le Goff
    INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
  • Evelyne Peuchant
    INSERM, Centre INSERM U876, F-33000, Bordeaux, France
    CHU de Bordeaux, F-33000, Bordeaux, France
  • Joseph Colin
    Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Service d’Ophtalmologie, CHU de Bordeaux, F-33000, Bordeaux, France
  • Pascale Barberger-Gateau
    INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
  • Cécile Delcourt
    INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
    Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France
  • Footnotes
    Commercial Relationships  Benedicte Merle, None; Marie-Noëlle Delyfer, Laboratoires Théa (C); Jean-François Korobelnik, Laboratoires Théa (C); Marie-Bénédicte Rougier, Laboratoires Théa, Merk Serono (C); Florence Malet, None; Mélanie Le Goff, None; Evelyne Peuchant, None; Joseph Colin, None; Pascale Barberger-Gateau, Vifor Pharma; lecture fees Bausch & Lomb, Danone Institute, Lesieur and Aprifel (C); Cécile Delcourt, Bausch&Lomb, Laboratoires Théa, Novartis (C)
  • Footnotes
    Support  Conseil Régional Aquitaine
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3813. doi:https://doi.org/
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    • Get Citation

      Benedicte Merle, Marie-Noëlle Delyfer, Jean-François Korobelnik, Marie-Bénédicte Rougier, Florence Malet, Mélanie Le Goff, Evelyne Peuchant, Joseph Colin, Pascale Barberger-Gateau, Cécile Delcourt; Plasma omega3 fatty acids and the risk for age-related macular degeneration: the Alienor Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3813. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

High dietary intake of omega3 polyunsaturated fatty acids (PUFA) and fish have been consistently associated with a decreased risk for age-related macular degeneration (AMD). We report the associations of late AMD with plasma concentrations of omega3 PUFA, which represent a more objective assessment of omega3 PUFA status.

 
Methods:
 

The Alienor study is a prospective population-based study on nutrition and age-related eye diseases, performed in 963 residents of Bordeaux (France), aged 73 years or more. Participants are re-examined every two years since baseline (2006-2008). Plasma fatty acids were measured by gas chromatography, from fasting blood samples collected in 1999-2001. Late AMD (geographic atrophy and/or neovascular AMD) was graded from non mydriatic colour retinal photographs taken in 2006-2008 (baseline), and 2009-2011 (first follow-up). Associations of late AMD with plasma omega3 PUFA were estimated using Generalized Estimating Equation logistic regressions, after adjustment for potential confounders (age, gender, smoking, education, physical activity, plasma HDL-cholesterol, plasma triglycerides, fruits consumption, CFH Y402H, apoE4 and ARMS2 A69S polymorphisms and follow-up time). Of 963 subjects, 84 (8.7%) had no gradable photographs, 167 (17.3%) had missing data for plasma fatty acids and 107 (11.1%) for confounders, leaving 605 subjects (1170 gradable eyes) for the statistical analysis, including 96 eyes with prevalent (58) and incident (38) late AMD.

 
Results:
 

After multivariate adjustment, higher plasma total omega3 PUFA was associated with reduced risk for prevalent late AMD with borderline significance (OR=0.69 for 1-standard deviation increase, 95% confidence interval (CI): 0.46-1.04, p=0.08) and significantly with incident late AMD (OR=0.51, 95% CI: 0.28-0.92, p=0.02). When combining prevalent and incident cases, the association was highly significant (OR=0.62, 95% CI: 0.43-0.88, p=0.008). Associations were similar for plasma alpha-linolenic acid (for combined cases OR=0.62, 95% CI: 0.43-0.88, p=0.008) and long-chain omega3 PUFA (for combined cases OR=0.65, 95% CI: 0.46-0.92, p=0.01).

 
Conclusions:
 

This study shows an inverse association of late AMD with plasma omega3 PUFA, consistent with previous observations concerning dietary intakes.

 
Keywords: age-related macular degeneration • nutritional factors • clinical (human) or epidemiologic studies: risk factor assessment 
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