Purchase this article with an account.
Marie-Noelle Delyfer, Marie-Benedicte Rougier, Joseph Colin, Florence Malet, Mélanie Le-Goff, Jean-François Dartigues, Cécile Delcourt, Jean-Francois Korobelnik; Detection Of Late Age-Related Macular Degeneration Using SD-OCT In A Population-Based Setting: The Alienor Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3817.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
We investigated the contribution of SD-OCT imaging for the detection of late neovascular and atrophic AMD in a population-based setting.
The ALIENOR (Antioxydants, LipidesEssentiels, Nutrition and maladies OculaiRes) Study is a population-based epidemiological study on age-related eye diseases. In 2009-2010, 625 subjects, aged 75 years or more, had an eye examination, including non mydriatic retinal colour photographs and examination with Spectralis SD-OCT (Heidelberg, Germany). AMD was graded from retinal photographs in 5 exclusive groups: late neovascular AMD; late atrophic AMD (geographic atrophy); large soft indistinct drusen and/or reticular drusen and/or large distinct drusen with pigment abnormalities (early AMD2); large soft distinct drusen alone or pigment abnormalities alone (early AMD1); no AMD. SD-OCT examinations were graded by a retina specialist for presence of atrophy and signs of neovascular AMD (subretinal fluid, subretinal tissue, pigment epithelium detachment, intra-retinal fluid). Graders of retinal photographs were masked to OCT interpretations, and vice versa. Gradable retinal photographs and SD-OCT examinations were available in 935 eyes.
Of 27 eyes classified as neovascular AMD on colour photographs, 24 (88.9 %) were also classified as neovascular AMD on SD-OCT examinations. Conversely, 16 of 40 eyes (40.0 %) classified as neovascular AMD on SD-OCT examinations were not detected on retinal photographs. Similarly, of 38 eyes classified as geographic atrophy on colour photographs, 30 (79.0 %) were also classified as atrophic AMD on SD-OCT examinations. Conversely, 19 of 49 eyes (38.8 %) classified as atrophic AMD on SD-OCT examinations were not detected on retinal photographs. Respectively 11.3% and4.5 % and only 0.3 % of eyes classified as early AMD2, early AMD1 and no AMD from retinal photographs were diagnosed as late AMD on SD-OCT examinations.
Both retinal photographs and SD-OCT examinations give information for the detection of late AMD, but SD-OCT examinations appear markedly more sensitive. Use of SD-OCT examinations, which are quick and not invasive, may be useful for the detection of initiating late AMD lesions in subjects with signs of early AMD on retinal photographs.
This PDF is available to Subscribers Only