March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Drusen and Geographic Atrophy Quantification by Optical Coherence Tomography in an Elderly Amish Population
Author Affiliations & Notes
  • Damien C. Rodger
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • Bruno Diniz, Sr.
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Sun Young Lee
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • Tine MacKay
    University of Pennsylvania, Philadelphia, Pennsylvania
  • Dwight Stambolian
    University of Pennsylvania, Philadelphia, Pennsylvania
  • Srinivas R. Sadda
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • Footnotes
    Commercial Relationships  Damien C. Rodger, None; Bruno Diniz, Sr., None; Sun Young Lee, None; Tine MacKay, None; Dwight Stambolian, None; Srinivas R. Sadda, Carl Zeiss Meditec (F), Heidelberg Engineering (C), Optovue, Inc. (F), Topcon Medical Systems, Inc. (P)
  • Footnotes
    Support  This work was supported in part by the Beckman Institute for Macular Research and the Research to Prevent Blindness Physician Scientist Award.
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3828. doi:
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      Damien C. Rodger, Bruno Diniz, Sr., Sun Young Lee, Tine MacKay, Dwight Stambolian, Srinivas R. Sadda; Drusen and Geographic Atrophy Quantification by Optical Coherence Tomography in an Elderly Amish Population. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3828.

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Abstract
 
Purpose:
 

To describe optical coherence tomography (OCT) derived measures of drusen and geographic atrophy (GA) in an elderly Amish population and correlate these OCT findings with other demographic features.

 
Methods:
 

Members of the Amish community in Pennsylvania ages 50 and older underwent macular color fundus photography and Cirrus OCT volume scanning (Carl Zeiss Meditec Inc, Dublin, CA) using a 200x200 raster protocol. Quantitative measurements of drusen area and volume, as well as of GA, were obtained in the macula within a circle of 3 mm diameter (central zone) and a surrounding ring from 3 mm to 5 mm diameter (perifoveal zone), centered on the fovea, using the Cirrus OCT RPE analysis research software (6.0.0.599). Demographic features analyzed included gender, age group (separated into 50-59, 60-69, 70-79, and >80 years of age), continuous age, smoking status, years smoked, and systolic blood pressure (SBP).

 
Results:
 

434 eyes of 217 consecutive subjects were included in this analysis. Drusen area and volume measurements were similar between males and females, but GA area was significantly higher in women (0.63 ± 0.16 vs. 0.26 ± 0.08 mm2). The mean area and volume of drusen and area of GA correlated significantly with age group (p<0.001), with similar correlation coefficients (r=0.21-0.25). The perifoveal drusen area continuously increased with age, while central zone drusen area stabilized after age 70 (0.25 ± 0.06mm2 at 70-79 years old and 0.25 ± 0.07mm2 for ages 80 and over). Drusen volume in the central zone was smaller after age 80 (0.009 ± 0.003 mm3) when compared to the 70-79 year old group (0.02 ± 0.008 mm3). GA area continuously increased with age. Drusen measurements were similar between smokers and non-smokers but the perifoveal drusen area (p=0.05) and volume (p=0.005) increased with continuous years smoked when adjusted for age. Drusen area and volume in the perifoveal zone continuously increased with SBP, and GA area was also found to be directly associated with SBP. There was high correlation of the drusen area and volume and GA area between right and left eyes. Drusen area and volume correlated significantly between the central and perifoveal zones (p<0.001), and GA area was correlated with increased drusen area and volume in both zones.

 
Conclusions:
 

In this Amish population, age appears to be an important risk factor for increased drusen area and volume in the perifoveal zone, and in the central zone only until age 70. Drusen and GA measurements were highly correlated between the two eyes of the same subject. Number of continuous years smoked and SBP were associated with increased perifoveal drusen area and volume. Increased GA area was associated with female gender, age, and SBP.

 
Keywords: drusen • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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