March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Specific Tear IgE in Seasonal Allergic Conjunctivitis with ImmunoCAP Rapid
Author Affiliations & Notes
  • Tatsuya Mimura
    Department of Ophthalmology, Univ of Tokyo Grad School of Med, Bunkyo-ku, Japan
  • Satoru Yamagami
    Ophthalmology, Univ of Tokyo Sch of Med, Bunkyo-ku, Japan
  • Tomohiko Usui
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • Takashi Miyai
    Ophthalmology, University of Tokyo Hospital, Bunkyo-ku, Japan
  • Shiro Amano
    Ophthalmology, Univ of Tokyo School of Medicine, Bunkyo-Ku, Japan
  • Footnotes
    Commercial Relationships  Tatsuya Mimura, None; Satoru Yamagami, None; Tomohiko Usui, None; Takashi Miyai, None; Shiro Amano, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3998. doi:
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    • Get Citation

      Tatsuya Mimura, Satoru Yamagami, Tomohiko Usui, Takashi Miyai, Shiro Amano; Specific Tear IgE in Seasonal Allergic Conjunctivitis with ImmunoCAP Rapid. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3998.

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      © ARVO (1962-2015); The Authors (2016-present)

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To evaluate whether ImmnoCAP Rapid™, a new commercial immunochromatographic test for measurement of specific IgE, could be used as a screening test for the diagnosis of allergic conjunctivitis.


A prospective, nonrandomized, cross-sectional study was conducted in 34 moderate to severe cases of allergic conjunctivitis (allergic group) and 30 age- and sex-matched healthy control subjects (control group). Specific IgE levels for cedar pollen, ragweed, mugwort, and orchard grass, cat epithelium and dander, dog dander, Dermatophagoides pteronyssinus, and cockroach were measured in tear fluid with the ImmnoCAP Rapid.


Specific IgE levels in tear fluid could be assayed within 20 minutes in all subjects. The positive rate of specific IgE was higher in the allergic group than in the control group (cedar pollen,100.0% vs. 3.3%; D. pteronyssinus, 97.1% vs. 3.3%; orchard grass, 88.2% vs. 3.3%; mugwort, 32.4% vs. 0.0%; ragweed 29.4% vs. 0.0%; cat epithelium, 14.7% vs. 0.0%; cockroach, 8.6% vs. 0.0%; and cat epithelium, 23.4% vs. 0.0%).


These results suggest that ImmnoCAP Rapid is a rapid and easy test for detection of allergen-specific IgE in tear fluid samples from patients with allergic conjunctivitis.

Keywords: anterior segment • conjunctivitis 

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