April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Evaluation of Systane Balance for Normalization of Blink Patterns in a Dry Eye Population
Author Affiliations & Notes
  • Mayur M. Contractor
    Dry Eye, Ora, Inc., Andover, Massachusetts
  • Joseph M. Griffin
    Global Scientific Market Affairs, Alcon Research Ltd, Fort Worth, Texas
  • Keith Lane
    Dry Eye, Ora, Inc., Andover, Massachusetts
  • George W. Ousler, III
    Dry Eye, Ora, Inc., Andover, Massachusetts
  • Endri Angjeli
    Dry Eye, Ora, Inc., Andover, Massachusetts
  • Stephanie L. Breton
    Dry Eye, Ora, Inc., Andover, Massachusetts
  • Richard Abelson
    Statistics and Data Corporation, Tempe, Arizona
  • Mark B. Abelson
    Dry Eye, Ora, Inc., Andover, Massachusetts
    Schepens Eye Research Institute and Harvard Medical School, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  Mayur M. Contractor, Ora, Inc. (E); Joseph M. Griffin, Alcon Research Ltd (E); Keith Lane, Ora, Inc. (E); George W. Ousler, III, Ora, Inc. (E); Endri Angjeli, Ora, Inc. (E); Stephanie L. Breton, Ora, Inc. (E); Richard Abelson, Statistics and Data Corporation (E); Mark B. Abelson, Ora, Inc. (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3830. doi:
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      Mayur M. Contractor, Joseph M. Griffin, Keith Lane, George W. Ousler, III, Endri Angjeli, Stephanie L. Breton, Richard Abelson, Mark B. Abelson; Evaluation of Systane Balance for Normalization of Blink Patterns in a Dry Eye Population. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3830.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : The relative frequency of partial blinks in normal and Dry Eye subjects has relevance to tear film breakup and corneal exposure. Our research has previously shown that blink patterns in patients with high levels of ocular discomfort are associated shorter inter-blink intervals and a higher proportion of full versus partial blinks. To date, no artificial tear has been shown to normalize blink proportions and inter-blink intervals. We investigated the relative proportion of full blinks in a Dry Eye population treated with Systane Balance, a novel artificial tear designed to restore lipid layer integrity and enhance tear film stability. The relative proportion of full blinks was investigated using the OPI 2.0 System (Abelson 2010.)

Methods: : Blink statistics were measured for a subject population of 31 Dry Eye patients at two visits one week apart. The visual task assigned was viewing a documentary. Each visit consisted of a baseline measurement after which Systane was administered. Measurements were made at 10 minutes and 55 minutes after treatment. On days between the two visits, patients were instructed to administer Systane Balance four times per day. The blink statistics were measured using the OPI 2.0 system at each visit.

Results: : Results show that the proportion of full blinks decreased for the population mean by 20% from the initial visit to the final visit (p=0.045). Compared to baseline, the proportion of full blinks at the 55 minute time point decreased by 14% and 18% at the initial and follow-up visit respectively (p=0.075).Additionally, at the pre-treatment time point there was an inverse relationship between the proportion of full blinks and the inter-blink interval (IBI) (correlation = -0.30, p=0.076).

Conclusions: : In this study, treatment with Systane Balance significantly increased the normalization of the blink pattern suggesting a beneficial effect.

Clinical Trial: : http://www.clinicaltrials.gov NCT01223040

Keywords: cornea: tears/tear film/dry eye • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 

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