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Allison Rand, Maxwell Pistilli, Ellen Peskin, Hilary Smolen, Peter G. Dentone, John Farrar, Maureen G. Maguire, Penny A. Asbell; Correlation of a Global Assessment with Dry Eye Questionnaires in Evaluating Symptoms of Dry Eye Disease. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3861.
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To evaluate clinician and patient Global Assessments of Dry Eye Disease (DED) as compared to three individual DED questionnaires (Brief Ocular Discomfort Inventory - BODI, Ocular Surface Disease Index - OSDI, and Impact of Dry Eye on Everyday Life - IDEEL) as standardized measures of patient DED symptoms.
Prior to ophthalmic examination on two separate visits, patients with DED completed each of the three individual questionnaires, and a one-question global assessment of their symptoms quantifying dry eye severity on a scale of 1 to 10, with 10 being most severe. These results were masked from examining clinicians, who also examined the patient at each visit and completed a global assessment. At the second visit, the patients were also asked to assess change in symptoms between examinations. Spearman statistical analysis was used to determine an estimate of correlation between Global Assessment responses and each of the individual questionnaire responses.
Compared to the 237 global assessments completed at visit 1, BODI had the highest response correlation at 0.75, followed by IDEEL at 0.73, and OSDI at 0.59. The OSDI to BODI correlation was 0.69. The OSDI to IDEEL correlation was 0.77. The BODI to IDEEL correlation was 0.75. The patient to clinician correlation on respective global assessments was 0.23. Comparing change between examinations 1 and 2 in 181 responses, the BODI had the highest statistically significant correlation at 0.5 as compared to the patient global assessment.
There is low correlation between clinician and patient perceptions of DED based on both questionnaire and Global Assessment responses. Our results suggest the BODI questionnaire best expresses the response of the patient Global Assessment. There is relatively high correlation amongst all three questionnaires at the first examination, but again, the BODI stands out as the survey that best correlates to the change in patient DED symptoms between examinations.
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