April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Association Between Non Arteritic Anterior Ischaemic Optic Neuropathy And Sleep Apnoea Syndrome
Author Affiliations & Notes
  • Hafid Khayi
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • Christopher Chiquet
    Department of Ophthalmology,
    Grenoble University Hospital, Grenoble, France
    Inserm ERI 17, Joseph Fourier University, Grenoble, France
  • Jean Louis Pepin, Sr.
    Rehabilitation and physiology department,
    Grenoble University Hospital, Grenoble, France
    Inserm ERI 17, Joseph Fourier University, Grenoble, France
  • Elisabeth Renard
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • Karine Palombi
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • Patrick Levy
    Rehabilitation and physiology department,
    Grenoble University Hospital, Grenoble, France
    Inserm ERI 17, Joseph Fourier University, Grenoble, France
  • Jean-Paul Romanet
    Ophthalmology,
    Grenoble University Hospital, Grenoble, France
  • Footnotes
    Commercial Relationships  Hafid Khayi, None; Christopher Chiquet, None; Jean Louis Pepin, Sr., None; Elisabeth Renard, None; Karine Palombi, None; Patrick Levy, None; Jean-Paul Romanet, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3881. doi:
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      Hafid Khayi, Christopher Chiquet, Jean Louis Pepin, Sr., Elisabeth Renard, Karine Palombi, Patrick Levy, Jean-Paul Romanet; Association Between Non Arteritic Anterior Ischaemic Optic Neuropathy And Sleep Apnoea Syndrome. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3881.

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Abstract

Purpose: : To evaluate the association between newly non arteritic anterior optic neuropathy (NAION) and obstructive sleep apnoea syndrome (OSA).

Methods: : Newly NAION patients underwent polysomnography after a complete clinical examination. The prevalence of OSA in NAION patients was compared to the prevalence previously found in the general population. Other potential risk factors associated with NAION were also identified: cup/disk ratio, optic disk size, hypertension, diabetes, hyperlipidaemia, tobacco smoking and atheromatous lesions of carotid vessels.

Results: : One hundred twenty one consecutive newly diagnosed patients with NAION were screened consecutively during a 6 year period (2004-2009). Patients with giant cell arteritis (n=9) and patients refusing the polysomnography (n=16) were excluded from the analysis. In the population of 96 NAION patients (61 men and 35 women, mean age 68 ± 9 years, body mass index 27 ± 4 kg/m²) included in this study, 82 patients (85%) were diagnosed as having OSA (respiratory disturbance index: 39.5 ± 21.8/h). The prevalence of OSA found in this study was significantly higher than that found in an age-matched population (4 -9%, p<0.001) and the risk ratio for a NAION patient to have sleep apnoea was 4.7 compared to the general population (p<0.001). Prevalence of other risk factors was not significantly different between patients with or without OSA.

Conclusions: : This new prospective study on a large series of NAION patients confirmed that sleep apnoea is the most frequent disorder associated with NAION and should be screened in this population. In addition to a sleep questionnaire, polysomnography should be systematically proposed to patients with NAION

Clinical Trial: : http://www.clinicaltrials.gov NCT00874913

Keywords: neuro-ophthalmology: optic nerve • clinical (human) or epidemiologic studies: risk factor assessment 
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