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Hafid Khayi, Christopher Chiquet, Jean Louis Pepin, Sr., Elisabeth Renard, Karine Palombi, Patrick Levy, Jean-Paul Romanet; Association Between Non Arteritic Anterior Ischaemic Optic Neuropathy And Sleep Apnoea Syndrome. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3881.
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To evaluate the association between newly non arteritic anterior optic neuropathy (NAION) and obstructive sleep apnoea syndrome (OSA).
Newly NAION patients underwent polysomnography after a complete clinical examination. The prevalence of OSA in NAION patients was compared to the prevalence previously found in the general population. Other potential risk factors associated with NAION were also identified: cup/disk ratio, optic disk size, hypertension, diabetes, hyperlipidaemia, tobacco smoking and atheromatous lesions of carotid vessels.
One hundred twenty one consecutive newly diagnosed patients with NAION were screened consecutively during a 6 year period (2004-2009). Patients with giant cell arteritis (n=9) and patients refusing the polysomnography (n=16) were excluded from the analysis. In the population of 96 NAION patients (61 men and 35 women, mean age 68 ± 9 years, body mass index 27 ± 4 kg/m²) included in this study, 82 patients (85%) were diagnosed as having OSA (respiratory disturbance index: 39.5 ± 21.8/h). The prevalence of OSA found in this study was significantly higher than that found in an age-matched population (4 -9%, p<0.001) and the risk ratio for a NAION patient to have sleep apnoea was 4.7 compared to the general population (p<0.001). Prevalence of other risk factors was not significantly different between patients with or without OSA.
This new prospective study on a large series of NAION patients confirmed that sleep apnoea is the most frequent disorder associated with NAION and should be screened in this population. In addition to a sleep questionnaire, polysomnography should be systematically proposed to patients with NAION
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