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Xiaojun Zhang, Ning Lu, Nan Jia, Xiuyun Kong; Risk Of Stroke After Acute Ischemic Retinal Events In China. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3889.
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To investigate risk of developing stroke in Chinese acute ischemic retinal events(AIRE) patients and the correlated risk factors.
AIRE patients were prospectively collected. While clinical data was recorded, internal carotid artery(ICA) and cardiac ultrasound, blood test for hypercoagulation and vasculitis were tested. Patients were followed up for visual outcome and new cerebral or retinal stroke. Data was statistically analyzed to see the correlated high risk factors of stroke after AIRE.
In 102 of 128 AIRE cases (79.7%) which had 1-year follow-up, cerebral stroke was reported in 13 cases(12.7%, 95%CI,6.2%-19.2%) . The cumulate risk of cerebral stroke was 2.0%(95%CI,0-4.7%) within 7 days,3.9%(95%CI,0.2%-7.6%) within 2 weeks,7.8%(95%CI,2.5%-13.1%) within 1month,9.8%(95%CI,4.1%-15.5%)within 3 months and 10.8%(95%CI,4.7%-16.9%)within 6 months since AIRE. In 35 cases of retinal transient ischemic attack (R-TIA), 17 cases (48.6%, 95%CI,32.1%-65.1%) had retinal stroke and 5 cases(14.3%(95%CI,2.7%-25.9%) had cerebral stroke during the follow-up. Severe carotid artery stenosis, past medical history of ischemic cardiac attack and cerebral stroke were found to be significantly correlated with higher risk of stroke after AIRE.
While totally 12.7% of AIRE patients had cerebral stroke within 1 year, 9.8% happened with 3 months. Retinal stroke occurred to nearly a half of R-TIA patient. Severe carotid artery stenosis, history of ischemic cardiac attack and cerebral stroke were found to be the high risk factors for stroke in AIRE group.
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