April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Occipital Fmri Response Is Associated With Structural Ocular Findings And Psychophysics Tests In Glaucoma Patients
Author Affiliations & Notes
  • Augusto Paranhos
    Depto de Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Vanessa M. Gerente
    Depto de Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Ruth R. Schor
    Depto de Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Sergio H. Teixeira
    Depto de Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
  • Marcelo Felix
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Dora F. Ventura
    Pysichology Institute, Sao Paulo University, Sao Paulo, Brazil
  • Claudio L. Lottenberg
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Khallil T. Chaim
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Edson Amaro
    Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil
  • Footnotes
    Commercial Relationships  Augusto Paranhos, MSD and Allergan (C); Vanessa M. Gerente, None; Ruth R. Schor, None; Sergio H. Teixeira, None; Marcelo Felix, None; Dora F. Ventura, None; Claudio L. Lottenberg, None; Khallil T. Chaim, None; Edson Amaro, None
  • Footnotes
    Support  Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP (Grant: 2007/07339-2)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3962. doi:
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      Augusto Paranhos, Vanessa M. Gerente, Ruth R. Schor, Sergio H. Teixeira, Marcelo Felix, Dora F. Ventura, Claudio L. Lottenberg, Khallil T. Chaim, Edson Amaro; Occipital Fmri Response Is Associated With Structural Ocular Findings And Psychophysics Tests In Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3962.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The purpose of this study was to evaluate the functional magnetic resonance imaging (fMRI) response to visual stimuli and its association with structural ocular findings and psychophysics tests in patients with glaucoma and controls.

Methods: : Patients and controls performed the following exams: SAP 24-2, FDT Matrix and Stratus OCT. fMRI was performed with a 3 Tesla MRI, with 2 patterns of a reversing checkerboard visual stimuli, an expanding ring (eccentricity) and a rotating wedge (polar angle). Stimuli were presented bilaterally in 3 cycles of 60 seconds each. Visual cortex response was obtained by changes in blood flow oxygenation: BOLD (blood oxygen level dependent) effect. BOLD response was analyzed in 3 ways: "fMRI measure" was defined as the maximum peak of the BOLD response, with a delay of 3 seconds; "BOLD 90%" is the value obtained by the analysis of BOLD feat query of the FSL, and is calculated based on the predictors and the voxels considered the largest range of cumulative distribution; and "occipital response" is the average of the most significant values in the occipital pole ROI. Perimetry (SAP and FDT) results were divided into quadrants, using the average of the total deviation for each quadrant, excluding the central point that corresponds to macula. Superior and inferior average RNFL thickness were also compared to fMRI response. To compare both groups regarding anatomical and functional examinations, generalized estimating equation (GEE) models were performed.

Results: : Results: 20 individuals performed the exams, 14 with glaucoma and 6 controls. Mean age was 59.3 ± 14.8 years for control group and 61.7 ± 10.5 years for glaucoma group. Regarding polar angle stimulus, there was a statistically significant association with fMRI measure for SAP (p=<0,001) and FDT (p=0,044), and with bold90% (p=0,042) and occipital response (p=0,025) for OCT. For eccentricity stimulus, a statistically significant association was observed bold90% (p=0,015) for SAP, fMRI measure (p=0,003) and bold90% (p=0,045) for FDT and fMRI measure (p=0,029) and occipital response (p=0,001) for OCT.

Conclusions: : Glaucoma patients have a decreased functional cortical response to visual stimuli associated with the magnitude of the visual field loss seen in SAP and FDT and RNFL thickness by OCT.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • perimetry • nerve fiber layer 
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