April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Evaluation Of Optic Nerve And Optic Nerve Sheath Diameter In Primary Open Angle Glaucoma With 3-Tesla Magnetic Resonance Imaging
Author Affiliations & Notes
  • Ningli Wang
    Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  • Xiaobin Xie
    Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  • Diya Yang
    Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  • Ruojin Ren
    Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  • Junfang Xian
    Radiology, Beijing Tongren Hospital, Beijing, China
  • Yong Li
    Radiology, Beijing Tongren Hospital, Beijing, China
  • Zheng Zhang
    Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  • Jinghong Sang
    Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  • Footnotes
    Commercial Relationships  Ningli Wang, None; Xiaobin Xie, None; Diya Yang, None; Ruojin Ren, None; Junfang Xian, None; Yong Li, None; Zheng Zhang, None; Jinghong Sang, None
  • Footnotes
    Support  Beijing YXBS Grant PXM2010_014226_07_000061
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3963. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ningli Wang, Xiaobin Xie, Diya Yang, Ruojin Ren, Junfang Xian, Yong Li, Zheng Zhang, Jinghong Sang; Evaluation Of Optic Nerve And Optic Nerve Sheath Diameter In Primary Open Angle Glaucoma With 3-Tesla Magnetic Resonance Imaging. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3963.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Previous investigations have suggested that low intracranial pressure (ICP), which increased the trans-lamina cribrosa pressure difference (TLCPD), may play an important role in the pathogenesis of Normal Tension Glaucoma (NTG). However, the relationship between ICP measured by lumbar puncture and the cerebrospinal fluid pressure (CSFP) around the optic nerve is still in vague. Since no direct measurement of local CSFP around optic nerve can be performed to date intravitally on human. We proposed measuring of the Optic Nerve Sheath Diameter (ONSD) and Optic Nerve Diameter (OND) by 3.0-Tesla MRI as a substitute to evaluate the local CSFP around optic nerve in patients diagnosed POAG.

Methods: : 27 POAG patients, in whom 13 NTG patients and 14 high IOP patients (HPG group) and 16 subjects without eye diseases served as control were enrolled in this study. ONSD and OND were determined at 3mm, 9mm, and 15mm behind the eye ball with T2-weighted fast recovery fast spin echo (FRFSE) fat suppressed sequence in 3.0-Tesla MRI providing a spatial resolution of 0.16mm. An ANOVA with post-hoc LSD multiple comparisons were used to analyze the data among the three groups. A P<0.05 was required for results to be considered statistically significant.

Results: : At 3mm behind the eye ball, there has no significant difference of OND among three groups; but the ONSD of NTG group is significantly narrower than control group (p<0.05). At 9mm, the OND of HPG group is significantly narrower than the other two groups (P<0.05); For ONSD at 9mm, the NTG group and HPG group are both significantly narrower than the control group (P<0.05). At 15mm, the OND of NTG group and HPG group are both significantly narrower than the control group (P<0.05); For ONSD at 15mm, the NTG group and HPG group are both significantly narrower than the control group (P<0.05).

Conclusions: : This study directly shows that in Normal Tension Glaucoma patients the ONSD is narrow, which correspond well with our previous work and suggest that the local CSFP around ON in NTG patients is low and lead to an elevated TLCPD. The optic nerve diameter of open angle glaucoma patients is shrunk along with the optic nerve length and this shrinkage also retracts the optic nerve sheath, which may further block the CSF circulation between the subarachnoid space of optic nerve and brain at the further site of the optic nerve length behind the eye ball and may lead to a more elevated TLCPD in a long term manner.

Keywords: optic nerve • lamina cribrosa • imaging/image analysis: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×