April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Significant Role Of Serous Retinal Detachment For Va-gain After Intravitreal Triamcinolone Treatment In Patients With Uveitis-associated Cystoid Macular Edema
Author Affiliations & Notes
  • Marion R. Munk
    Dept of Ophthalmology, Medical University Vienna, Vienna, Austria
  • Matthias Bolz
    Dept of Ophthalmology, Medical University Vienna, Vienna, Austria
  • Wolfgang Huf
    Dept of statistics and probability theory, Technical University Vienna, Vienna, Austria
  • Florian Sulzbacher
    Dept of Ophthalmology, Medical University Vienna, Vienna, Austria
  • Stefan Eisenkoelbl
    Dept of Ophthalmology, Medical University Vienna, Vienna, Austria
  • Rene Rueckert
    Global Clinical Development, Bayer Health Care AG, Berlin, Germany
  • Christopher G. Kiss
    Dept of Ophthalmology, Medical University Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Marion R. Munk, None; Matthias Bolz, None; Wolfgang Huf, None; Florian Sulzbacher, None; Stefan Eisenkoelbl, None; Rene Rueckert, None; Christopher G. Kiss, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3969. doi:
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      Marion R. Munk, Matthias Bolz, Wolfgang Huf, Florian Sulzbacher, Stefan Eisenkoelbl, Rene Rueckert, Christopher G. Kiss; The Significant Role Of Serous Retinal Detachment For Va-gain After Intravitreal Triamcinolone Treatment In Patients With Uveitis-associated Cystoid Macular Edema. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3969.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To gain insight into morphological and functional aspects of uveitis-associated cystoid macular edema (CME) using high resolution optical coherence tomography (HD-OCT)

Methods: : Twenty-eight eyes with uveitis-associated CME were prospectively examined before and after intravitreal triamcinolone injection (IVTA) up to month 3. Retinal morphological changes including cyst size, distribution and development, the layer integrity and subretinal detachment (SRD) configuration was precisely evaluated using HD-OCT technology. HD-OCT findings were correlated to functional aspects, such as best corrected visual acuity (BCVA)

Results: : Uveitis-associated CME -in contrast to CME of other origin - showed a very characteristic denture-like appearance: Following IVTA, first the big foveal cysts diminished, followed by the small parafoveally located incisor like organized INL cysts. Fifteen of 28 eyes with CME showed SRD before treatment initiation which resolution lagged behind cyst disappearance. Within a CME relapse, INL cysts first developed, followed by typical big centrally located cysts, whereas no subject showed new- or reappearance of SRD within observation period. Presence of initial SRD was a predictor for a relapse free clinical course, whereas almost 75% of subjects without SRD showed a cyst relapse

Conclusions: : Uveitis-associated CME presents very characteristic morphologic alteration discernible from CME of other origin. SRD is a predictor for a good BCVA outcome following IVTA treatment

Keywords: imaging/image analysis: clinical • edema • uveitis-clinical/animal model 
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