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Marion R. Munk, Matthias Bolz, Wolfgang Huf, Florian Sulzbacher, Stefan Eisenkoelbl, Rene Rueckert, Christopher G. Kiss; The Significant Role Of Serous Retinal Detachment For Va-gain After Intravitreal Triamcinolone Treatment In Patients With Uveitis-associated Cystoid Macular Edema. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3969.
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© ARVO (1962-2015); The Authors (2016-present)
To gain insight into morphological and functional aspects of uveitis-associated cystoid macular edema (CME) using high resolution optical coherence tomography (HD-OCT)
Twenty-eight eyes with uveitis-associated CME were prospectively examined before and after intravitreal triamcinolone injection (IVTA) up to month 3. Retinal morphological changes including cyst size, distribution and development, the layer integrity and subretinal detachment (SRD) configuration was precisely evaluated using HD-OCT technology. HD-OCT findings were correlated to functional aspects, such as best corrected visual acuity (BCVA)
Uveitis-associated CME -in contrast to CME of other origin - showed a very characteristic denture-like appearance: Following IVTA, first the big foveal cysts diminished, followed by the small parafoveally located incisor like organized INL cysts. Fifteen of 28 eyes with CME showed SRD before treatment initiation which resolution lagged behind cyst disappearance. Within a CME relapse, INL cysts first developed, followed by typical big centrally located cysts, whereas no subject showed new- or reappearance of SRD within observation period. Presence of initial SRD was a predictor for a relapse free clinical course, whereas almost 75% of subjects without SRD showed a cyst relapse
Uveitis-associated CME presents very characteristic morphologic alteration discernible from CME of other origin. SRD is a predictor for a good BCVA outcome following IVTA treatment
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