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Ryan M. St Clair, Anton Orlin, Grant D. Aaker, Luis Gracia, Jane S. Myung, Vanessa Borcherding, Jason R. Banfelder, Szilard Kiss; Three-Dimensional Volumetric ‘Cast’ of the Choroid Using Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4034.
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© ARVO (1962-2015); The Authors (2016-present)
Despite advances in choroidal imaging using enhanced depth imaging(EDI) optical coherence tomography (OCT), measurements haveuntil now been limited to estimating choroidal thickness fromsingle two-dimensional (2D) OCT slices. Here, we describe anovel method for reconstucting 2D EDI OCT data for three-dimensional(3D) choroidal analysis and volume measurement.
Two male patients, age 52 and 65, with no known retinal or choroidalpathology, were selected for EDI OCT imaging. Images were obtainedby positioning a Heidelberg Spectralis spectral-domain OCT deviceclose enough to the eye to acquire an inverted image. 145 individualEDI OCT images were obtained from a 20 x 15 degree area centeredaround the fovea, with 30 micrometers between sections. Choroidalblood vessels were outlined manually in each section. 3D imageswere generated and choroidal volume was calculated with Avizosoftware (Avizo® (6.1.1, Visualization Sciences Group, Burlington,MA) using a custom buit plug-in developed at this institution.
The resulting 3D images were equivalent to a "cast" of choroidalvessels. Choroidal volume of patient 1 was 1.683 mm3. Choroidalvolume of patient 2 was 1.751 mm3
3D volumetric reconstructions of EDI OCT images offer a novelmethod for quantifying and qualifing the choroid. 3D reconstructionof the choroidal vessels may lead to better understanding ofmacular degeneration, central serous retinopathy, and otherdisease states.
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