April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Three-Dimensional Volumetric ‘Cast’ of the Choroid Using Enhanced Depth Imaging Optical Coherence Tomography
Author Affiliations & Notes
  • Ryan M. St Clair
    Ophthalmology, Weill Cornell Medical College, New York, New York
  • Anton Orlin
    Ophthalmology, Weill Cornell Medical College, New York, New York
  • Grant D. Aaker
    Ophthalmology, Weill Cornell Medical College, New York, New York
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, New York
  • Luis Gracia
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, New York
  • Jane S. Myung
    Ophthalmology, Weill Cornell Medical College, New York, New York
  • Vanessa Borcherding
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, New York
  • Jason R. Banfelder
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, New York
  • Szilard Kiss
    Ophthalmology, Weill Cornell Medical College, New York, New York
  • Footnotes
    Commercial Relationships  Ryan M. St Clair, None; Anton Orlin, None; Grant D. Aaker, None; Luis Gracia, Research to Prevent Blindness, the David A. Cofrin Center for Biomedical Information (F); Jane S. Myung, None; Vanessa Borcherding, None; Jason R. Banfelder, Research to Prevent Blindness and the David A. Cofrin Center for Biomedical Information (F); Szilard Kiss, Research to Prevent Blindness,the David A. Cofrin Center for Biomedical Information (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4034. doi:
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      Ryan M. St Clair, Anton Orlin, Grant D. Aaker, Luis Gracia, Jane S. Myung, Vanessa Borcherding, Jason R. Banfelder, Szilard Kiss; Three-Dimensional Volumetric ‘Cast’ of the Choroid Using Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4034.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Despite advances in choroidal imaging using enhanced depth imaging(EDI) optical coherence tomography (OCT), measurements haveuntil now been limited to estimating choroidal thickness fromsingle two-dimensional (2D) OCT slices. Here, we describe anovel method for reconstucting 2D EDI OCT data for three-dimensional(3D) choroidal analysis and volume measurement.

 
Methods:
 

Two male patients, age 52 and 65, with no known retinal or choroidalpathology, were selected for EDI OCT imaging. Images were obtainedby positioning a Heidelberg Spectralis spectral-domain OCT deviceclose enough to the eye to acquire an inverted image. 145 individualEDI OCT images were obtained from a 20 x 15 degree area centeredaround the fovea, with 30 micrometers between sections. Choroidalblood vessels were outlined manually in each section. 3D imageswere generated and choroidal volume was calculated with Avizosoftware (Avizo® (6.1.1, Visualization Sciences Group, Burlington,MA) using a custom buit plug-in developed at this institution.

 
Results:
 

The resulting 3D images were equivalent to a "cast" of choroidalvessels. Choroidal volume of patient 1 was 1.683 mm3. Choroidalvolume of patient 2 was 1.751 mm3

 
Conclusions:
 

3D volumetric reconstructions of EDI OCT images offer a novelmethod for quantifying and qualifing the choroid. 3D reconstructionof the choroidal vessels may lead to better understanding ofmacular degeneration, central serous retinopathy, and otherdisease states.  

 

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • choroid • imaging/image analysis: clinical 
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