April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
"Correlation between Axial Length and Retinal and Optic Nerve Head Parameters as Measured by Fourier Domain Optical Coherence Tomography"
Author Affiliations & Notes
  • Veronica C. Lima
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology, Hospital Oftalmológico Medicina dos Olhos, Sao Paulo, Brazil
  • Paulo Dantas
    Ophthalmology, Hospital Oftalmológico Medicina dos Olhos, Sao Paulo, Brazil
  • Marcelo I. Dimantas
    Ophthalmology, Hospital Oftalmológico Medicina dos Olhos, Sao Paulo, Brazil
  • Fabio N. Kanadani
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Tiago S. Prata
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology, Hospital Oftalmológico Medicina dos Olhos, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  Veronica C. Lima, None; Paulo Dantas, None; Marcelo I. Dimantas, None; Fabio N. Kanadani, None; Tiago S. Prata, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4053. doi:
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      Veronica C. Lima, Paulo Dantas, Marcelo I. Dimantas, Fabio N. Kanadani, Tiago S. Prata; "Correlation between Axial Length and Retinal and Optic Nerve Head Parameters as Measured by Fourier Domain Optical Coherence Tomography". Invest. Ophthalmol. Vis. Sci. 2011;52(14):4053.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the correlation between axial length (AL) and retinal and optic nerve head (ONH) parameters provided by a Fourier Domain optical coherence tomography (FD-OCT) device.

Methods: : We have prospectively enrolled 34 healthy subjects. After a complete ophthalmic examination, those with any ocular disease were excluded. Data collected included age, refractive error and AL (determined by ultrasound biometry). All subjects underwent FD-OCT imaging in one randomly selected eye. Parameters evaluated were: average peripapillary retinal nerve fiber layer (avRNFL) thickness, foveal thickness, average macular ganglion cell complex thickness (avGCC; consisting of RNFL, ganglion cell and inner plexiform layers), ONH area and rim area. Multiple regression analysis (controlling for patient’s age) was used to investigate the association between AL and each of these FD-OCT parameters.

Results: : Mean (±SD) age and spherical equivalent of participants were 44.4±12.8 (range, 18 to 83) years and -1.25±2.4 diopters (range, -7.00 to +3.00 D), respectively. Mean values for each FD-OCT parameter evaluated were: AL= 23.9±1.0 mm, foveal thickness= 259.9±20.7 µm, avGCC thickness= 93.8±8.1 µm, avRNFL thickness= 105.5±12.2 µm, ONH area= 2.1±0.5 mm2 and rim area= 1.1±0.4 mm2. Factors significantly correlated with AL were avGCC (r2=0.47, p<0.001), avRNFL (r2=0.51, p<0.001) and ONH area (R2=0.58, p<0.001). Patients with greater AL had thinner RNFL and GCC thicknesses, but no significant correlation was found between AL and total foveal thickness (p=0.64). Patients with greater AL had smaller ONH areas, but no significant correlation was found between AL and rim area (p=0.16).

Conclusions: : In cases within -7.00 to +3.00 D of refractive error, the axial length of the globe seems to significantly influence the thickness of the inner retinal layers, but not the total foveal thickness. In addition, eyes with larger globes seem to have smaller discs when evaluated by FD-OCT.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical • nerve fiber layer 
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