Purchase this article with an account.
Veronica C. Lima, Paulo Dantas, Marcelo I. Dimantas, Fabio N. Kanadani, Tiago S. Prata; "Correlation between Axial Length and Retinal and Optic Nerve Head Parameters as Measured by Fourier Domain Optical Coherence Tomography". Invest. Ophthalmol. Vis. Sci. 2011;52(14):4053.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the correlation between axial length (AL) and retinal and optic nerve head (ONH) parameters provided by a Fourier Domain optical coherence tomography (FD-OCT) device.
We have prospectively enrolled 34 healthy subjects. After a complete ophthalmic examination, those with any ocular disease were excluded. Data collected included age, refractive error and AL (determined by ultrasound biometry). All subjects underwent FD-OCT imaging in one randomly selected eye. Parameters evaluated were: average peripapillary retinal nerve fiber layer (avRNFL) thickness, foveal thickness, average macular ganglion cell complex thickness (avGCC; consisting of RNFL, ganglion cell and inner plexiform layers), ONH area and rim area. Multiple regression analysis (controlling for patient’s age) was used to investigate the association between AL and each of these FD-OCT parameters.
Mean (±SD) age and spherical equivalent of participants were 44.4±12.8 (range, 18 to 83) years and -1.25±2.4 diopters (range, -7.00 to +3.00 D), respectively. Mean values for each FD-OCT parameter evaluated were: AL= 23.9±1.0 mm, foveal thickness= 259.9±20.7 µm, avGCC thickness= 93.8±8.1 µm, avRNFL thickness= 105.5±12.2 µm, ONH area= 2.1±0.5 mm2 and rim area= 1.1±0.4 mm2. Factors significantly correlated with AL were avGCC (r2=0.47, p<0.001), avRNFL (r2=0.51, p<0.001) and ONH area (R2=0.58, p<0.001). Patients with greater AL had thinner RNFL and GCC thicknesses, but no significant correlation was found between AL and total foveal thickness (p=0.64). Patients with greater AL had smaller ONH areas, but no significant correlation was found between AL and rim area (p=0.16).
In cases within -7.00 to +3.00 D of refractive error, the axial length of the globe seems to significantly influence the thickness of the inner retinal layers, but not the total foveal thickness. In addition, eyes with larger globes seem to have smaller discs when evaluated by FD-OCT.
This PDF is available to Subscribers Only