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Carmen M. Colitz, Sarah N. Miller, Judy St. Leger, Richard R. Dubielzig; Ocular Histopathological Lesions Of The Pinniped Eye: A Retrospective Evaluation. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4084.
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To document the ocular histopathology using a database at Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW).
Seventy submissions were reviewed from three separate databases all housed in the COPLOW laboratory. Based on the microscopic findings, eyes were separated into the following categories, which are not mutually exclusive: normal, non-inflammatory corneal disease, metastatic cancer, amyloid, phthisis bulbi, keratitis, cataract, and trauma.
Results are presented for each individual regardless of whether one or both eyes were submitted. Six distinct species are represented, but Zalophus californianus alone accounted for 50 submissions. Twenty-nine pinnipeds had at least one normal globe. Abnormalities were seen in 47 specimens: 6 with metastatic cancer, 4 with amyloid, 8 with phthisis bulbi, 8 with traumatic disease, 23 with cataracts, and 41 with corneal disease. Animals with corneal disease were further categorized:27 animals had epithelial changes, 22 had endothelial attenuation, 26 had stromal changes, 5 has keratitis, 7 had Descemet’s pathology, 10 had membranes, and 6 had synechia. Corneal epithelial changes consisted of epithelial attenuation, separation, and disorganization or dysplasia. Stromal changes were always hypercellularity and loss of the lamellar organization. Endothelial changes were attenuation often with rupture of the very delicate Descemet's membrane.
The majority of captive otariid species had pathological findings consistent with the clinical entity presently called Otariid Keratitis which involved all anatomic segments of the cornea; this suggests a primary degenerative process suspected to have a UV component. This is the first report of ocular amyloid in pinniped eyes. The presence of metastatic cancer in 6 individuals suggests it is a fairly common finding.
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