April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Novel Corneal Hydration Imaging Technology Using Terahertz Illumination
Author Affiliations & Notes
  • R D. Johnson
    Jules Stein Eye Institute, Los Angeles, California
  • David B. Bennett
    Retina, Electrical Engineering,
    Center for Advanced Surgical and Interventional Technology (CASIT), University of California Los Angeles, University of California Los Angeles, California
    University of California Los Angeles, Los Angeles, California
  • Zachary D. Taylor
    Ophthalmology, Center for Advanced Surgical and Interventional Technology (CASIT),
    Bioengineering,
    University of California Los Angeles, Los Angeles, California
  • Jean P. Hubschman
    Retina, Electrical Engineering,
    Jules Stein Eye Institute, Los Angeles, California
    Center for Advanced Surgical and Interventional Technology (CASIT), University of California Los Angeles, Los angeles, California
  • Daniel Sassoon
    Ophthalmology, Center for Advanced Surgical and Interventional Technology (CASIT),
    Jules Stein Eye Institute, Los Angeles, California
  • Priyamvada Tewari
    Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, California
  • Martin Culjat
    University of California Los Angeles, Los Angeles, California
  • Elliott Brown
    Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, California
  • Raul S. Singh
    Ophthalmology, Center for Advanced Surgical and Interventional Technology (CASIT),
    University of California Los Angeles, Los Angeles, California
  • Warren S. Grundfest
    Ophthalmology, Center for Advanced Surgical and Interventional Technology (CASIT),
    Bioengineering,
    University of California Los Angeles, Los Angeles, California
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4092. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R D. Johnson, David B. Bennett, Zachary D. Taylor, Jean P. Hubschman, Daniel Sassoon, Priyamvada Tewari, Martin Culjat, Elliott Brown, Raul S. Singh, Warren S. Grundfest; Novel Corneal Hydration Imaging Technology Using Terahertz Illumination. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4092.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To assess the ability of imaging systems based on Terahertz illumination to measure corneal hydration.

Methods: : 9 ex vivo porcine corneas were soaked in a 0%, 3%, 5%, and 7% polyethylene glycol (PEG) solutions containing 0.15M NaCL for 3 days to produce corneas with water concentrations from 79.1% to 91.5% by volume. These tissues were then imaged using a Terahertz imaging system with an illumination frequency centered at 525 GHz ( = 570 µm)

Results: : A clear and consistent decrease in reflected THz intensity is seen in the corneas with reduced amounts of absorbed water. The hydration sensitivity (observed change in THz reflectivity for a given change in water concentration) calculated with calibration targets was 0.190% by volume. The THz imaging system provided a spatial resolution of ~ 1 mm enabling imaging of the cornea based on hydration.

Conclusions: : The increase or decrease of corneal hydration in several pathologies may impair its transparency. Currently, the only way to monitor corneal edema is through qualitative visual observation or indirect evaluation by serial quantitative thickness measurements. Terahertz illumination is a novel technology, which demonstrated its ability to assess corneal hydration and to clearly differentiate hydration status of ex vivo corneal tissue with very high sensitivity. The potential applications of this new imaging modality in the measurement and monitoring of corneal hydration in various pathologic corneal states may be promising.

Keywords: imaging/image analysis: clinical • cornea: clinical science • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×