April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Functional and Structural Rates of Glaucoma Progression Are Poorly Correlated
Nariman Nassiri; Naveed Nilforushan; Elena Bitrian; Dennis Mock; Anne L. Coleman; Simon K. Law; Joseph Caprioli; Kouros Nouri-Mahdavi
Author Affiliations & Notes
  • Nariman Nassiri
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Naveed Nilforushan
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Elena Bitrian
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Dennis Mock
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Anne L. Coleman
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Simon K. Law
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Joseph Caprioli
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Kouros Nouri-Mahdavi
    Ophthalmology/ Division of Glaucoma, Jules Stein Eye Institute/UCLA, Los Angeles, California
  • Footnotes
    Commercial Relationships  Nariman Nassiri, None; Naveed Nilforushan, None; Elena Bitrian, None; Dennis Mock, None; Anne L. Coleman, Allergan and Science Based Health (C); Simon K. Law, None; Joseph Caprioli, Allergan C,S; Pfizer S; Alcon S (C, R); Kouros Nouri-Mahdavi, Allergan C (C, R)
  • Footnotes
    Support  Partially supported by a grant from the Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4137. doi:
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      Nariman Nassiri, Naveed Nilforushan, Elena Bitrian, Dennis Mock, Anne L. Coleman, Simon K. Law, Joseph Caprioli, Kouros Nouri-Mahdavi; Functional and Structural Rates of Glaucoma Progression Are Poorly Correlated. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4137.

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Abstract

Purpose: : To explore correlation of structural and functional rates of glaucoma progression over time with confocal laser ophthalmoscopy (HRT) and standard achromatic visual fields.

Methods: : One hundred seventeen eyes (76 patients) with definite or suspected glaucoma with >5 good-quality HRT images (pixel SD less than 50 microns) and >5 reliable achromatic visual fields during at least 3 years of follow-up were selected from the UCLA’s Glaucoma Division clinical database. The date of the first and last visual fields and HRT images were required to be within 6 months of each other. HRT’s global/sectoral rim area and visual field mean deviation (MD) and the average loss in visual field clusters (based on Garway-Heath structure-function maps) were regressed against follow-up time to estimate rates of progression. The correlation between structural and functional rates of progression in eyes showing a negative trend for global or sectoral rim area over time (p <0.15) was explored with bivariate correlation analysis.

Results: : The mean (± SD) follow-up time was 9.3 ± 3.0 years and the median baseline MD was -3.5 (range: 2.9 to -30.3). The median (range) number of HRT images and visual field exams were 6 (5-10) and 12 (6-34), respectively. The superotemporal (median rate: -0.0013 mm2/year) and inferotemporal sectors (median rate: -0.001 mm2/year) were the sectors with fastest progression rates. A significant correlation between rates of progression was found between HRT’s superotemporal sector and inferior peripheral (Spearman’s r =0.45; p =0.004) and midperipheral visual field clusters (r =0.48; p =0.002) and between HRT’s superonasal sector and inferior peripheral (r =0.60; p <0.001) and midperipheral visual field clusters (r =0.45; p =0.008). The results did not change significantly when only eyes with MD <-8 dB were reanlayzed.

Conclusions: : The correlation between structural and functional rates of progression was not uniform across disc sectors and visual field regions and was moderate at best. Functional and structural tests should both be used for estimating rates of progression in glaucoma.

Keywords: visual fields • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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