April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Sensitivity and Specificity of a Series of Glaucoma Change Probability Criteria
Author Affiliations & Notes
  • Gideon J. Zamba
    Biostatistics, University of Iowa, College of Public Health, Iowa City, Iowa
  • Carrie K. Doyle
    Veterans Affairs Medical Center, Iowa City, Iowa
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Chris A. Johnson
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Michael Wall
    Veterans Affairs Medical Center, Iowa City, Iowa
    Neurology and Ophthalmology, University of Iowa, College of Medicine, Iowa City, Iowa
  • Footnotes
    Commercial Relationships  Gideon J. Zamba, None; Carrie K. Doyle, None; Chris A. Johnson, None; Michael Wall, None
  • Footnotes
    Support  VA Merit Review
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4154. doi:
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      Gideon J. Zamba, Carrie K. Doyle, Chris A. Johnson, Michael Wall; Sensitivity and Specificity of a Series of Glaucoma Change Probability Criteria. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4154.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Many combinations of abnormality have been proposed for defining progression using the glaucoma change probability (GCP) method. We tested a series of criteria varying the number of abnormal test locations from 2-8 and the number of visits where the abnormality was confirmed to determine which combination had the optimum sensitivity and specificity.

Methods: : Sixty (60) normal subjects and 120 glaucoma patients were tested every six months for 4 years with SITA standard. We compared 60 combinations of the presence of repeated abnormal test locations at consecutive and semi-consecutive visits (tests confirmed at 2 consecutive, 3 consecutive, 2 of 3 visits, 3 of 4 and 2 of 4 each, at visual field locations ranging from 2 to 8).

Results: : The optimal methods were: More than two locations confirmed in 3 out of 4 consecutive visits (sensitivity 67%-- specificity 80%). More than three locations confirmed in 3 out of 4 consecutive visits (sensitivity 60%-- specificity 83%). More than eight locations confirmed in 2 out of 4 consecutive visits (sensitivity 65%-- specificity 82%). GCP (2x4), GCP (8, 2x4) and GCP (3x4) (Vesti et al. 1999) show sub-optimality with respect to the change detection methods found above.

Conclusions: : The presence of 4 or more abnormal test locations confirmed on semi-consecutive visits may be clinically useful and efficient methods of defining visual field change in glaucoma

Keywords: visual fields 
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