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Gideon J. Zamba, Carrie K. Doyle, Chris A. Johnson, Michael Wall; Sensitivity and Specificity of a Series of Glaucoma Change Probability Criteria. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4154.
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Many combinations of abnormality have been proposed for defining progression using the glaucoma change probability (GCP) method. We tested a series of criteria varying the number of abnormal test locations from 2-8 and the number of visits where the abnormality was confirmed to determine which combination had the optimum sensitivity and specificity.
Sixty (60) normal subjects and 120 glaucoma patients were tested every six months for 4 years with SITA standard. We compared 60 combinations of the presence of repeated abnormal test locations at consecutive and semi-consecutive visits (tests confirmed at 2 consecutive, 3 consecutive, 2 of 3 visits, 3 of 4 and 2 of 4 each, at visual field locations ranging from 2 to 8).
The optimal methods were: More than two locations confirmed in 3 out of 4 consecutive visits (sensitivity 67%-- specificity 80%). More than three locations confirmed in 3 out of 4 consecutive visits (sensitivity 60%-- specificity 83%). More than eight locations confirmed in 2 out of 4 consecutive visits (sensitivity 65%-- specificity 82%). GCP (2x4), GCP (8, 2x4) and GCP (3x4) (Vesti et al. 1999) show sub-optimality with respect to the change detection methods found above.
The presence of 4 or more abnormal test locations confirmed on semi-consecutive visits may be clinically useful and efficient methods of defining visual field change in glaucoma
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