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Namita Bhardwaj, Mitra Sehi, Wei Shi, David S. Greenfield, Advanced Imaging in Glaucoma Study Group; Macular Ganglion Cell Thickness Measurements Using Fourier-Domain OCT for Prediction of Glaucomatous Progression. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4163.
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© ARVO (1962-2015); The Authors (2016-present)
To assess whether baseline macular ganglion cell loss thickness measured with fourier-domain OCT (FDOCT) is associated with glaucoma progression.
Glaucoma suspect and glaucomatous eyes with ≥30 months of follow-up meeting eligibility criteria were prospectively enrolled. All eyes underwent standard automated perimetry (SAP; SITA Standard 24-2), and FDOCT imaging (RTVue, Optovue Inc., Fremont, CA) every six months. Progression was assessed using pointwise linear regression (PLR) of SAP sensitivity values using Progressor TM software, and was defined as ≥ 2 contiguous locations in the same hemifield with sensitivity loss of >1dB/year at p<0.01. Macular imaging was performed over a 7x6 mm region and ganglion cell complex (GCC) measurements, consisting of nerve fiber, ganglion cell, and inner plexiform layers, were obtained. Baseline GCC, SAP mean and pattern standard deviation, IOP, and central corneal thickness were included in a logistic regression model.
One eye of 33 glaucoma suspects (mean age 63±9 yrs) and 20 patients with glaucoma (mean age 65± 11 yrs) were enrolled with a mean follow-up of 2.7 ± 0.21 yrs. Average baseline SAP mean deviation was -3.77±3.9 dB in glaucomatous eyes. Three eyes (6%) consisting of 2 glaucoma suspects and 1 glaucomatous eye demonstrated SAP progression. Average GCC (84.9 and 83.2 µM), superior GCC (84.3 and 84.0 µM), inferior GCC (85.4 and 82.5 µM), superior-inferior difference (-1.2 and 1.5 µM), focal loss volume (4.8 % and 4.8%), and global loss volume (13.7% and 14.8%) were similar (p>0.3) in progressing and non-progressing eyes, respectively. Multiple logistic regression models demonstrated no significant association between glaucoma progression and baseline macular GCC thickness.
Baseline macular ganglion cell thickness measures were not predictive of glaucomatous progression in this cohort.
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