April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
African Descent And Glaucoma Study (ADAGES): Comparison Of Rates Of Glaucomatous Progressive Nerve Fiber Layer Loss Between Patients Of European Descent And African-descent
Mauro T. Leite; Linda M. Zangwill; Robert N. Weinreb; Christopher Bowd; Ali Tafreshi; Kaweh Mansouri; Christopher A. Girkin; Jeffrey M. Liebmann; Pamela A. Sample; Felipe A. Medeiros
Author Affiliations & Notes
  • Mauro T. Leite
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
    Ophthalmology, Federal Univ of Sao Paulo, Sao Paulo, Brazil
  • Linda M. Zangwill
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
  • Robert N. Weinreb
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
  • Christopher Bowd
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
  • Ali Tafreshi
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
  • Kaweh Mansouri
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
  • Christopher A. Girkin
    Ophthalmology, School of Medicine - Univ of Alabama, Birmingham, Alabama
  • Jeffrey M. Liebmann
    Ophthalmology, NYU School of Medicine, New York, New York
  • Pamela A. Sample
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
  • Felipe A. Medeiros
    Ophthalmology, Hamilton Glaucoma Center - UCSD, La Jolla, California
    Ophthalmology, Federal Univ of Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  Mauro T. Leite, None; Linda M. Zangwill, Carl Zeiss Meditec, Inc. (F), Heidelberg Engineering GmbH (R), Heidelberg Engineering, GmbH (F), Topcon Medical Systems (F); Robert N. Weinreb, Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Carl Zeiss Meditec, Inc. (C, F), Heidelberg Engineering, GmbH (F), Merck (C), Novartis (F), Optovue (C), Optovue, Inc. (F), Pfizer (C), Topcon Medical Systems, Inc. (F); Christopher Bowd, Pfizer, Inc. (F); Ali Tafreshi, None; Kaweh Mansouri, None; Christopher A. Girkin, Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Carl Zeiss Meditec (R), Heidelberg Engineering Inc. (R), Merck (R), Optive (R), Pfizer, Inc. (C), Topcon Medical Systems (R); Jeffrey M. Liebmann, Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Carl Zeiss Meditec, Inc. (F), Dyopsis Corp. (F, C), Heidelberg Enginnering (F), Optovue Inc. (F, C), Topcon Medical System Inc. (C), Topcon Medical Systems, Inc. (F); Pamela A. Sample, Carl Zeiss Meditec, Inc. (F), Haag-Streit (F); Felipe A. Medeiros, Alcon Laboratories Inc. (F), Alcon Laboratories, Inc. (C, R), Allergan, Inc. (C, R), Carl Zeiss Meditec Inc. (F), Carl Zeiss Meditec, Inc. (R), Merck Inc. (F), Pfizer Inc. (F), Pfizer, Inc. (C, R), Reichert, Inc. (R)
  • Footnotes
    Support  NEI EY11008, NEI EY08208, U10EY14267, EY019869, EY08208, EY11008, EY13959
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4167. doi:
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      Mauro T. Leite, Linda M. Zangwill, Robert N. Weinreb, Christopher Bowd, Ali Tafreshi, Kaweh Mansouri, Christopher A. Girkin, Jeffrey M. Liebmann, Pamela A. Sample, Felipe A. Medeiros; African Descent And Glaucoma Study (ADAGES): Comparison Of Rates Of Glaucomatous Progressive Nerve Fiber Layer Loss Between Patients Of European Descent And African-descent. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4167.

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Abstract

Purpose: : To compare the rates of retinal nerve fiber layer (RNFL) loss, as measured by scanning laser polarimetry with enhanced corneal compensation (GDx ECC), in a cohort of African Descent (AD) and European Descent (ED) glaucoma and glaucoma suspect patients followed over time.

Methods: : This was an observational cohort study. Three hundred and ten eyes (187 ED and 123 AD) with glaucoma or suspected of having the disease were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Study (ADAGES). Included eyes had to have at least 4 GDx ECC images and a minimum follow-up period of 2 years. Random coefficient models were used to evaluate the relationship between changes in RNFL thickness (global, inferior and superior) over time and ancestry. Fast progression was arbitrarily defined as an average RNFL loss greater than 2µm/yr.

Results: : The average follow-up time was 3.4 years (SD:±0.71; range: 2 to 5.5 years). Average, inferior and superior RNFL thickness had a significant decrease over time in both racial groups. No statistically significant difference was detected between AD and ED for the rates of RNFL change. For the average RNFL thickness, rates of change were -0.35µm/yr for AD and -0.51µm/yr for ED (P=0.136). For the inferior RNFL thickness, rates of change were -0.29µm/yr for AD and -0.54µm/yr for ED (P=0.097). For the superior RNFL thickness, the rates of change were -0.69µm/yr for AD and -0.82µm/yr for ED (P=0.387). Considering a range of "useful" average RNFL thickness of 40µm, based on previously reported residual thickness values the mean rates of RNFL loss per year would correspond to 1.8%/yr in ED and 1.3%/yr in AD for the average thickness parameter. The proportion of patients who had fast progression was 4.8% in ED and 5.7% in AD.

Conclusions: : RNFL thickness measurements obtained with the GDxECC showed significant decrease over time in glaucoma patients and suspects. Rates of RNFL loss were similar in AD and ED patients.

Clinical Trial: : http://www.clinicaltrials.gov NCT00221897

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • clinical (human) or epidemiologic studies: natural history 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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