April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The European Glaucoma Optic Disc Appraisal study for Progression (EGODAP online study)
Author Affiliations & Notes
  • Thierry Zeyen
    Ophthalmology, University Hospitals Leuven, Leuven, Belgium
  • Hans G. Lemij
    Glaucoma Service, Rotterdam Eye Hospital, Rotterdam, The Netherlands
  • Joseph Caprioli
    Glaucoma, Jules Stein Eye Institute, UCLA, Los Angeles, California
  • Ingeborg Stalmans
    Ophthalmology, University Hospitals Leuven, Leuven, Belgium
  • David F. Garway-Heath
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  Thierry Zeyen, Pfizer (R); Hans G. Lemij, None; Joseph Caprioli, None; Ingeborg Stalmans, None; David F. Garway-Heath, Carl Zeiss Meditec (C), Carl Zeiss Meditec, Heidelberg (R), Carl Zeiss Meditec, Heidelberg, and OptoVue (F)
  • Footnotes
    Support  Investigator initiated study supported by a grant from Pfizer.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4169. doi:
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    • Get Citation

      Thierry Zeyen, Hans G. Lemij, Joseph Caprioli, Ingeborg Stalmans, David F. Garway-Heath; The European Glaucoma Optic Disc Appraisal study for Progression (EGODAP online study). Invest. Ophthalmol. Vis. Sci. 2011;52(14):4169.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the agreement and diagnostic accuracy of European non-specialized ophthalmologists to evaluate serial optic disc color stereo photographs for glaucomatous change. To assess if the agreement and diagnostic accuracy changed after a training session.

Methods: : 88 ophthalmologists from 15 European countries classified online 54 eyes with varying severity of glaucoma as stable or progressing based on the appraisal of serial optic disc stereo photographs. The reference standard was the 2/3 agreement of three glaucoma experts. Progression was classified as obvious or subtle by the experts. Four photo’s were presented twice. Intra- and inter-observer agreement were assessed using kappa statistics .The sensitivity and specificity were calculated per rater and compared before and after a training session using Wilcoxon signed-rank tests.

Results: : The intra- and inter-observer agreement (Κ) increased from 0.63 to 0.86 (P=0.013), and from 0.34 to 0.42 (P<0.0001) respectively after the training session. The sensitivity and specificity increased from 63.3% to 66.2% (P=0.021), and from 79.5% to 85.4% (P<0.001) respectively after the training session. The sensitivity in detecting obvious change increased from 78.4% to 86% (P<0.0001) after the training session.

Conclusions: : The agreement and diagnostic accuracy of European non-specialized ophthalmologists in detecting glaucomatous progression by looking at serial optic disc stereo photos increased significantly after a training session.

Keywords: optic disc • imaging/image analysis: clinical • learning 
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