April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment Trial
Author Affiliations & Notes
  • H Nida Sen
    National Eye Institute, National Institutes of Health, Bethesda, Maryland
  • Lea T. Drye
    Department of Epidemiology, School of Public Health,
    The Johns Hopkins University, Baltimore, Maryland
  • Debra A. Goldstein
    Ophthalmology, Univ of Illinois at Chicago, Chicago, Illinois
  • Theresa A. Larson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland
  • Pauline T. Merrill
    Ophthalmology, Rush University, Chicago, Illinois
  • Peter Reed Pavan
    University of South Florida, Tampa, Florida
  • John D. Sheppard, Jr.
    Ophthalmology, Eastern Virginia Medical Sch, Norfolk, Virginia
  • Alyce Burke
    Department of Epidemiology, School of Hygiene and Public Health,
    The Johns Hopkins University, Baltimore, Maryland
  • Sunil K. Srivastava
    Emory University Eye Center, Atlanta, Georgia
  • Douglas A. Jabs
    Ophthalmology, Mount Sinai School of Medicine, New York, New York
  • Footnotes
    Commercial Relationships  H Nida Sen, None; Lea T. Drye, None; Debra A. Goldstein, Bausch and Lomb (C); Theresa A. Larson, None; Pauline T. Merrill, None; Peter Reed Pavan, None; John D. Sheppard, Jr., None; Alyce Burke, None; Sunil K. Srivastava, None; Douglas A. Jabs, None
  • Footnotes
    Support  U10 EY 014655, U10 EY 014660, U10 EY 014656, NEI Intramural Research Program
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4269. doi:
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      H Nida Sen, Lea T. Drye, Debra A. Goldstein, Theresa A. Larson, Pauline T. Merrill, Peter Reed Pavan, John D. Sheppard, Jr., Alyce Burke, Sunil K. Srivastava, Douglas A. Jabs; Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment Trial. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4269.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the prevalence of hypotony and associated clinical features in patients with intermediate, posterior and panuveitis.

Methods: : The Multicenter Uveitis Steroid Treatment Trial (MUST), a 23-center prospective randomized study comparing treatments for intermediate, posterior and panuveitis, enrolled 255 patients. Patients with hypotony (IOP≤7) at the baseline visit were identified. Clinical and ocular characteristics associated with hypotony were assessed.

Results: : Among 251 patients with sufficient data (474 eyes), 24 patients (32 eyes) with hypotony were identified (9.7%); eight had bilateral hypotony (33%). The odds of hypotony were significantly higher in patients with chronic uveitis ≥5 yrs (OR: 5.9; 95% CI, 2.1 to 16.3; p<0.01) and sarcoidosis (OR: 3.5; 95% CI, 1.2 to 9.7; p:0.02). The odds of hypotony were lower in patients with older age (20-50 or ≥51) at the onset of uveitis (OR: 0.1, 95% CI,0.0 to 0.40 and OR: 0.3; 95% CI, 0.1 to 0.8; p≤ 0.01) compared to those with younger age at onset (<20), and in Caucasian patients (OR: 0.2; 95% CI, 0.1 to 0.5; p<0.01). The odds of hypotony were higher in eyes with pars planitis (OR: 3.3; 95% CI, 1.4 to 8.0; p:0.01) and when there was a history of glaucoma surgery (OR: 4.3; 95% CI, 1.8 to 10.1; p<0.01). Hypotony was associated with reduced visual acuity ≤ 20/50 (OR: 5.9; 95% CI, 2.3 to 15.3; p<0.01)

Conclusions: : Hypotony is an uncommon but important complication of chronic uveitis, and appears to preferentially affect patients with uveitis onset at a younger age, patients of non-Caucasian race and those with longstanding disease. It is associated with other serious ocular structural complications and low visual acuity.

Clinical Trial: : http://www.clinicaltrials.gov NCT00132691

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • intraocular pressure • uveitis-clinical/animal model 
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