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Dirk-Uwe G. Bartsch, Igor Kozak, Michael Goldbaum, Lingyun Cheng, Laurie Dustin, Stanley P. Azen, William R. Freeman; Correlation of Functional Color Vision Testing to Structural OCT Measures in Patients with HIV. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4273.
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To study the correlation between functional color vision testing and structural optical coherence tomography in patients with HIV and normal controls.
We retrospectively analyzed the records of three groups of patients. Patients with HIV and a CD4 nadir below 100 (Group L, n=36), patients with HIV and a CD4 above 100 (Group H, n=68) and normal age-matched controls (Group N, n=38). The subjects completed the Farnsworth Munsell 100 Hue color vision test and the total error score was recorded. In addition, we examined the patients by optical coherence tomography (StratusOCT) and performed a retinal nerve fiber layer thickness evaluation in circumpapillary scan with the high-resolution RNFL scan at a standard radius of 3.34 mm. We excluded any examinations where the software reported any missing data or low analysis confidence. We only included examinations with a signal strength of 5 or higher (scale 0-10). We segmented the RNFL data into the standard 4 sectors (superior, inferior, nasal and temporal). We used a relevance vector machine (RVM) and Pearson's correlation coefficient to study the correlation between the groups.
We found that the functional color vision test was significantly different between groups H and N, and between groups L and N. The difference between groups H and L was not significant. We found a negative correlation between the total error score (TES) and the superior and inferior RNFL quadrant (-0.32 and -0.16). We did not find a significant correlation between TES and RNFL thickness in the nasal or temporal quadrant. When we analyzed the three groups separately, we found that the best correlation was in group H (patients with HIV and high CD4 count).
We observed a negative correlation between retinal function as determined by Farnsworth Munsell 100 Hue test and structural measurements as determined by optical coherence tomography. The results indicate that a progressive loss of retinal nerve fiber layer thickness is associated with an increase in color vision defect. The correlation was highest in the superior and inferior quadrant of the optic nerve head.
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