Purchase this article with an account.
Jeong Hee Lee, Mohamed Ibrahim, Hyun Jin Kim, Hee-Yoon Cho, Elham Hatef, Afsheen Khwaja, Roomasa Channa, Jang Won Heo, Diana Do, Quan Dong Nguyen; Analyses Of Subfoveal Choroidal Thickness In Eyes With Non-infectious Uveitis Using Enhanced Depth Imaging. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4282.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To analyze subfoveal choroidal thickness in patients with non-infectious uveitis, with and without macular edema (ME), by enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)
Patients with intermediate, posterior, and panuveitis, with and without ME, and subjects with no known ocular diseases were enrolled. Subfoveal choroidal thickness and foveal thickness were measured using EDI OCT (Spectralis®, Heidelberg Engineering) by one grader. Best corrected visual acuity, intraocular pressure, and uveitic disease activity (degree of inflammation in anterior chamber, vitreous, and retina) were assessed by ETDRS chart, ophthalmic examination, and fluorescein angiography.
Thirty-five eyes with non-infectious uveitis due to intermediate (n=12), posterior (n=13), and panuveitis (n=10) have been analyzed. There were 17 eyes with uveitic macular edema (UME), 18 eyes with uveitis without ME, and 21 eyes with no known ocular diseases. Subfoveal choroidal thickness of patients with uveitis and UME was lower than uveitis without ME (p=0.034), but there was no significant difference between uveitic eyes without ME and control eyes. Foveal thickness was significantly correlated with subfoveal choroidal thickness in uveitic eyes with and without ME (r=-0.332) Presence of flare in anterior chamber and cells in vitreous cavity correlated with the presence of ME (p=0.004 and 0.0057, respectively). In eyes with UME, which correlates with presence of anterior chamber flare and vitreous cells, subfoveal choroidal thickness was lower than uveitic eyes without UME and eyes with no ocular diseases. Choroidal thickness also varied inversely with age (p<0.001).
EDI technology has allowed detailed imaging, measurements, and analyses of choroidal thickness in eyes with intermediate, posterior, and panuveitis. Eyes with UME appear to have thinner measured choroid than eyes without UME. Further studies are indicated to determine if ME leads to physiologic changes in the choroid or if the presence of choroidal thinness increases the likelihood of ME in eyes with uveitis.
This PDF is available to Subscribers Only