April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Analyses Of Subfoveal Choroidal Thickness In Eyes With Non-infectious Uveitis Using Enhanced Depth Imaging
Jeong Hee Lee; Mohamed Ibrahim; Hyun Jin Kim; Hee-Yoon Cho; Elham Hatef; Afsheen Khwaja; Roomasa Channa; Jang Won Heo; Diana Do; Quan Dong Nguyen
Author Affiliations & Notes
  • Jeong Hee Lee
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
    Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea
  • Mohamed Ibrahim
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Hyun Jin Kim
    Department of Ophthalmology,
    Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea
  • Hee-Yoon Cho
    Ophthalmology, Hanyang University, Kuri Hospital, Kuri, Kyeongki-do, Republic of Korea
  • Elham Hatef
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Afsheen Khwaja
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Roomasa Channa
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Jang Won Heo
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Diana Do
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Quan Dong Nguyen
    Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Woodstock, Maryland
  • Footnotes
    Commercial Relationships  Jeong Hee Lee, None; Mohamed Ibrahim, None; Hyun Jin Kim, None; Hee-Yoon Cho, None; Elham Hatef, None; Afsheen Khwaja, None; Roomasa Channa, None; Jang Won Heo, None; Diana Do, Generon, Genentech (F); Quan Dong Nguyen, Generon, Genentech (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4282. doi:
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      Jeong Hee Lee, Mohamed Ibrahim, Hyun Jin Kim, Hee-Yoon Cho, Elham Hatef, Afsheen Khwaja, Roomasa Channa, Jang Won Heo, Diana Do, Quan Dong Nguyen; Analyses Of Subfoveal Choroidal Thickness In Eyes With Non-infectious Uveitis Using Enhanced Depth Imaging. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4282.

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Abstract

Purpose: : To analyze subfoveal choroidal thickness in patients with non-infectious uveitis, with and without macular edema (ME), by enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)

Methods: : Patients with intermediate, posterior, and panuveitis, with and without ME, and subjects with no known ocular diseases were enrolled. Subfoveal choroidal thickness and foveal thickness were measured using EDI OCT (Spectralis®, Heidelberg Engineering) by one grader. Best corrected visual acuity, intraocular pressure, and uveitic disease activity (degree of inflammation in anterior chamber, vitreous, and retina) were assessed by ETDRS chart, ophthalmic examination, and fluorescein angiography.

Results: : Thirty-five eyes with non-infectious uveitis due to intermediate (n=12), posterior (n=13), and panuveitis (n=10) have been analyzed. There were 17 eyes with uveitic macular edema (UME), 18 eyes with uveitis without ME, and 21 eyes with no known ocular diseases. Subfoveal choroidal thickness of patients with uveitis and UME was lower than uveitis without ME (p=0.034), but there was no significant difference between uveitic eyes without ME and control eyes. Foveal thickness was significantly correlated with subfoveal choroidal thickness in uveitic eyes with and without ME (r=-0.332) Presence of flare in anterior chamber and cells in vitreous cavity correlated with the presence of ME (p=0.004 and 0.0057, respectively). In eyes with UME, which correlates with presence of anterior chamber flare and vitreous cells, subfoveal choroidal thickness was lower than uveitic eyes without UME and eyes with no ocular diseases. Choroidal thickness also varied inversely with age (p<0.001).

Conclusions: : EDI technology has allowed detailed imaging, measurements, and analyses of choroidal thickness in eyes with intermediate, posterior, and panuveitis. Eyes with UME appear to have thinner measured choroid than eyes without UME. Further studies are indicated to determine if ME leads to physiologic changes in the choroid or if the presence of choroidal thinness increases the likelihood of ME in eyes with uveitis.

Keywords: uveitis-clinical/animal model • imaging/image analysis: clinical • autoimmune disease 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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