April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
The Impact Of Macular Edema On Visual Function In Uveitis
Author Affiliations & Notes
  • Simon R. Taylor
    UCL Institute of Ophthalmology, London, United Kingdom
  • Sue Lightman
    UCL Institute of Ophthalmology, London, United Kingdom
  • Elizabeth A. Sugar
    Biostatistics/Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
  • Glenn J. Jaffe
    Ophthalmology, Duke University Eye Center, Durham, North Carolina
  • William R. Freeman
    Ophthalmology, UCSD Jacobs Retina Center, La Jolla, California
  • Michael M. Altaweel
    Ophthalmology & Visual Science, Univ of Wisconsin-Madison, Madison, Wisconsin
  • Igor Kozak
    Ophthalmology, UCSD Jacobs Retina Center, La Jolla, California
  • Janet T. Holbrook
    Epidemiology, Johns Hospkins Bloomberg School of Public Health, Baltimore, Maryland
  • Douglas A. Jabs
    Ophthalmology, Mount Sinai School of Medicine, New York, New York
  • John H. Kempen
    Ophthalmology/Biostatistics&Epidemiology, Scheie Eye Inst/Univ of Penn, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  Simon R. Taylor, None; Sue Lightman, None; Elizabeth A. Sugar, None; Glenn J. Jaffe, None; William R. Freeman, None; Michael M. Altaweel, None; Igor Kozak, None; Janet T. Holbrook, None; Douglas A. Jabs, None; John H. Kempen, None
  • Footnotes
    Support  The Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group is supported primarily by NEI Cooperative agreements: U10 EY 014655, U10 EY 014660, U10 EY 014656
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4309. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Simon R. Taylor, Sue Lightman, Elizabeth A. Sugar, Glenn J. Jaffe, William R. Freeman, Michael M. Altaweel, Igor Kozak, Janet T. Holbrook, Douglas A. Jabs, John H. Kempen; The Impact Of Macular Edema On Visual Function In Uveitis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4309.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : To evaluate the impact of macular edema on visual acuity and visual field sensitivity in intermediate, posterior and panuveitis.

Methods: : 255 patients (481 eyes with uveitis) recruited into the MUST Trial at 23 subspecialty centers underwent best-corrected visual acuity testing using ETDRS methods, Humphrey 24-2 visual field testing, and optical coherence tomography (OCT) at the same visit. OCT images were graded for measures of macular edema by trained graders at the study Reading Center.

Results: : Macular edema was associated with impaired visual acuity (P<0.01). Cystoid changes without retinal thickening ≥240 µm were associated with 1.2 lines’ reduction in visual acuity (-6 ETDRS letters); retinal thickening ≥240 µm without cystoid changes was associated with 2.6 lines’ reduction (-13 letters); and with both cysts and thickening with 3.6 lines’ reduction (-18 letters). Uveitis sufficient to satisfy the study’s inclusion criteria was associated with impaired visual field sensitivity as measured by mean deviation, but eyes with macular edema had even worse visual field sensitivity (P<0.01). Cystoid spaces only (-4.4 dB) had less impact than retinal thickening only (-5.9 dB); both cysts and thickening had the greatest negative impact on mean deviation (-6.9 dB).

Conclusions: : Macular edema substantially reduces visual function, suggesting that it is an important endpoint to study in the treatment of uveitis. As uveitis and macular edema both impair visual field sensitivity as measured by Humphrey 24-2 perimetry, both should be considered when evaluating patients with uveitis and raised intraocular pressure for glaucoma.

Clinical Trial: : http://www.clinicaltrials.gov NCT00132691

Keywords: uveitis-clinical/animal model • clinical (human) or epidemiologic studies: systems/equipment/techniques • imaging/image analysis: clinical 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.