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Luiz Felipe M. Barros, Ewaldo Mattos Jr, Diogo P. Rivelli, Cristina B. Hebeda, Silvia B. Barros, Paulo S M. Barros, Angelo J. Stopiglia; Effects Of Nepafenac 0,1% And Dexametasone 0,1% Eye Drops On Aqueous Humor Prostaglandin E2 And Ascorbic Acid Levels After Experimental Phacoemulsification In Rabbits. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4331.
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Purpose: The purpose of the this study was to compare the ascorbic acid levels and prostaglandin E2 levels of eyes treated with nepafenac 0,1% and dexametasone 0,1% eye drops after experimental phacoemulsification in rabbits
Methods: 21 animals were submitted to phacoemulsification of the right eye and divide into three groups: ST Group: moxifloxacin 0,5% eye drops 4 times a day; CORT Group: dexametasone 0,1% and moxifloxacin 0,5% eye drops 4 times a day; NEPA Group: nepafenac 0,1% and moxifloxacin 0,5% eye drops 4 times a day. Animals underwent clinical evaluation and values of intra-ocular pressure and central corneal pachimetry were assessed and samples of aqueous humor was taken immediately before surgical procedure and at days 1, 2, 3, 7 and 15 after surgery.
Results: NEPA group showed best results regarding to the clinical signs. Corneal pachimetry showed no difference between groups except at day 15 when groups CORT and NEPA that showed lower corneal pachimetry when compared to control group. Values of intra-ocular pressure showed no statistical difference except at day 1 when a peak was noted in CORT group (35,7 ± 10,73mmHg). The ascorbic acid levels of NEPA group were higher in all days but statistical difference was only observed at day 7 (640,57±271,67mM for NEPA versus 316,8±100,81mM for CORT and 511,35±235,36mM for ST) and day 15 (567,57± 92,08mM for NEPA versus 214,67±70,72mM for CORT and 676,65±278,35mM for ST). Regarding prostaglandin, NEPA group showed the lowest levels; however statistical difference was only observed at day 1 (57,1% of animals with PGE2 concentration <50pg/ml for NEPA versus 57,1% of animals with PGE2 levels between 51-500pg/ml for CORT and 60% of animals with PGE2 concentration >6400pg/ml for ST) and at day 2 (100% of animals with PGE concentration <50pg/ml for NEPA, 42,9% of animals with PGE levels between 51-500pg/ml for CORT and 33,3% of animals with PGE concentration >6400pg/ml for ST)
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