April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Investigating the Relationship between Macular Sensitivity, Retinal Thickness and Other Determinants in Eyes with Diabetic Macular Edema using Statistical Modeling
Farhad Rezaei; Elham Hatef Niami; Elizabeth Colantuoni; Mohamed Ibrahim; Yasir Sepah; Roomasa Channa; Afsheen Khwaja; Quan Dong Nguyen; Diana V. Do
Author Affiliations & Notes
  • Farhad Rezaei
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Elham Hatef Niami
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Elizabeth Colantuoni
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
  • Mohamed Ibrahim
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Yasir Sepah
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Roomasa Channa
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Afsheen Khwaja
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Diana V. Do
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  Farhad Rezaei, None; Elham Hatef Niami, None; Elizabeth Colantuoni, None; Mohamed Ibrahim, None; Yasir Sepah, None; Roomasa Channa, None; Afsheen Khwaja, None; Quan Dong Nguyen, None; Diana V. Do, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4467. doi:
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      Farhad Rezaei, Elham Hatef Niami, Elizabeth Colantuoni, Mohamed Ibrahim, Yasir Sepah, Roomasa Channa, Afsheen Khwaja, Quan Dong Nguyen, Diana V. Do; Investigating the Relationship between Macular Sensitivity, Retinal Thickness and Other Determinants in Eyes with Diabetic Macular Edema using Statistical Modeling. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4467.

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Abstract

Purpose: : To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME).

Methods: : 22 eyes of 11 patients with DME in a tertiary-care clinical practice were enrolled and underwent measurements with fundus microperimetry and retinal thickness tomography, using an automatic fundus perimetry/tomography system. Macular sensitivity, fixation pattern, and relationship between macular sensitivity, retinal thickness, and other determinants were quantified using mixed effect models with random variables.

Results: : Fixation stability revealed that 21 eyes (95.45%) had stable fixation (>75% within central 2° of point of fixation), and 1 eye (4.55%) had relatively unstable fixation (< 75% of fixation points located within 2°, > 75% located within 4). Evaluation of fixation location revealed that 15 eyes (68.18%) had central (> 50% of fixation points within 0.5mm of fovea); 3 eyes (13.64%) peri-central (25% to 50% within 0.5mm of fovea); and 4 eyes (18.18%) eccentric (< 25% of fixation points within 0.5mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03dB (95% confidence interval (CI): 0.00, 0.06) per 1µm increase in retinal thickness for thickness values ≤ 280µm measured with the OPKO/OTI spectral-domain OCT. The retinal sensitivity decreased by an average 0.05dB (95% CI: - 0.08, - 0.02) per 1µm increase in thickness for thickness values > 280µm.

Conclusions: : Our pilot study has provided novel information on the relationship among macular sensitivity, retinal thickness, and other parameters related to diabetic disease in patients with DME. There may be an optimal range of retinal thickness that correlates with optimal retinal sensitivity. Additional studies on microperimetry in DME are warranted to determine if microperimetry can be a reliable and reproducible method of quantifying macular function.

Keywords: diabetic retinopathy • perimetry • microscopy: fixation processing 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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