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Farhad Rezaei, Elham Hatef Niami, Elizabeth Colantuoni, Mohamed Ibrahim, Yasir Sepah, Roomasa Channa, Afsheen Khwaja, Quan Dong Nguyen, Diana V. Do; Investigating the Relationship between Macular Sensitivity, Retinal Thickness and Other Determinants in Eyes with Diabetic Macular Edema using Statistical Modeling. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4467.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME).
22 eyes of 11 patients with DME in a tertiary-care clinical practice were enrolled and underwent measurements with fundus microperimetry and retinal thickness tomography, using an automatic fundus perimetry/tomography system. Macular sensitivity, fixation pattern, and relationship between macular sensitivity, retinal thickness, and other determinants were quantified using mixed effect models with random variables.
Fixation stability revealed that 21 eyes (95.45%) had stable fixation (>75% within central 2° of point of fixation), and 1 eye (4.55%) had relatively unstable fixation (< 75% of fixation points located within 2°, > 75% located within 4). Evaluation of fixation location revealed that 15 eyes (68.18%) had central (> 50% of fixation points within 0.5mm of fovea); 3 eyes (13.64%) peri-central (25% to 50% within 0.5mm of fovea); and 4 eyes (18.18%) eccentric (< 25% of fixation points within 0.5mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03dB (95% confidence interval (CI): 0.00, 0.06) per 1µm increase in retinal thickness for thickness values ≤ 280µm measured with the OPKO/OTI spectral-domain OCT. The retinal sensitivity decreased by an average 0.05dB (95% CI: - 0.08, - 0.02) per 1µm increase in thickness for thickness values > 280µm.
Our pilot study has provided novel information on the relationship among macular sensitivity, retinal thickness, and other parameters related to diabetic disease in patients with DME. There may be an optimal range of retinal thickness that correlates with optimal retinal sensitivity. Additional studies on microperimetry in DME are warranted to determine if microperimetry can be a reliable and reproducible method of quantifying macular function.
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