April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Retinal Microstructural Changes And Visual Function In Acute Zonal Occult Outer Retinopathy
Author Affiliations & Notes
  • Tomotaka Wakazono
    kyoto university, Kyoto, Japan
  • Sotaro Ooto
    kyoto university, Kyoto, Japan
  • Masanori Hangai
    kyoto university, Kyoto, Japan
  • Kohei Takayama
    kyoto university, Kyoto, Japan
  • Naoko Arakawa
    kyoto university, Kyoto, Japan
  • Nagahisa Yoshimura
    kyoto university, Kyoto, Japan
  • Footnotes
    Commercial Relationships  Tomotaka Wakazono, None; Sotaro Ooto, None; Masanori Hangai, None; Kohei Takayama, None; Naoko Arakawa, None; Nagahisa Yoshimura, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4471. doi:
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      Tomotaka Wakazono, Sotaro Ooto, Masanori Hangai, Kohei Takayama, Naoko Arakawa, Nagahisa Yoshimura; Retinal Microstructural Changes And Visual Function In Acute Zonal Occult Outer Retinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4471.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To investigate the relationship between retinal function and structural changes by using fundus autofluorescence (FAF), spectral domain optical coherence tomography(SD-OCT), fundus-monitoring microperimetry (MP),and adaptive optics scanning laser ophthalmoscopy (AO-SLO) in eyes with acute zonal occult outer retinopathy (AZOOR).

Methods: : Participants were 5 eyes of 5 patients(2 men and 3 women; mean age, 48.6 years) with AZOOR. All patients underwent a full ophthalmologic examination, SD-OCT, FAF, and imaging with an original prototype AO-SLO system. The features obtained by these imaging modalities were compared with visual acuity and retinal sensitivity measured by MP.

Results: : SD-OCT images revealed disruptions in the photoreceptor inner segment/outer segment (IS/OS) junction in all the eyes. The mean retinal sensitivity was 14.6 ± 4.4 dB at the points where the IS/OS was intact, and 5.0 ± 6.0 dB where the IS/OS was disrupted (P < 0.001, Mann-Whitney U-test). The mean retinal sensitivity was 15.1 ± 3.0 dB at the points where the FAF signal was normal, and 6.1 ± 6.5 dB where the FAF signal was increased (P < 0.001, Mann-Whitney U-test). In all the eyes, AO-SLO images revealed large dark regions with small dark patches. In 1 eye, some dark regions were resolved, which corresponded to the retinal sensitivity recovery as revealed by MP.

Conclusions: : Retinal sensitivity was found to be influenced by IS/OS disruptions, and decreased retinal sensitivity corresponded to an increased FAF signal. AO-SLO revealed unique dark regions in the cone mosaic, which were related to retinal sensitivity. Such a condition may recover during the procedure.

Keywords: retina • retina: distal (photoreceptors, horizontal cells, bipolar cells) • imaging/image analysis: clinical 

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