April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Randomized Staining with Brilliant Blue or Indocyanine Green in Macular Hole and Pucker Surgery
Author Affiliations & Notes
  • Albert Caramoy
    Center of Ophthalmology,
    University of Cologne, Cologne, Germany
  • Bernd Kirchhof
    Center of Ophthalmology,
    University of Cologne, Cologne, Germany
  • Moritz Hahn
    Institute of Medical Statistics, Informatics, and Epidemiology,
    University of Cologne, Cologne, Germany
  • Sabine Schröder
    Center of Ophthalmology,
    University of Cologne, Cologne, Germany
  • Sascha Fauser
    Center of Ophthalmology,
    University of Cologne, Cologne, Germany
  • Philipp S. Muether
    Center of Ophthalmology,
    University of Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships  Albert Caramoy, None; Bernd Kirchhof, None; Moritz Hahn, None; Sabine Schröder, None; Sascha Fauser, None; Philipp S. Muether, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4500. doi:
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      Albert Caramoy, Bernd Kirchhof, Moritz Hahn, Sabine Schröder, Sascha Fauser, Philipp S. Muether; Randomized Staining with Brilliant Blue or Indocyanine Green in Macular Hole and Pucker Surgery. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4500.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report visual outcome after vitrectomy and internal limiting membrane (ILM) peeling using either indocyanine green (ICG) or brilliant blue (BB).

Methods: : Patients with idiopathic macular hole or macular pucker were randomly assigned (1:1) into a single center, single surgeon, non-inferiority study assessing ICG or BB as intravitreal ILM-dye. Follow up examination included Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, reading (Radner) visual acuity, clinical examinations, and optical coherence tomography. Main outcome measure was 1 year far and reading visual acuity. Non-inferiority margin was set at Δ=0.3.

Results: : 47 eyes were included in the analysis. In macular hole both far visual acuity (VA) and reading VA changes after 1 year do not show relevant differences (95% confidence interval (CI) -0.16 to 0,1 LogMAR and CI -0.33 to 0.11 LogRAD, respectively). In macular pucker VA changes for BB are inferior for reading VA, but not for far VA (CI -0.27 to 0.07 LogMAR and CI -0.29 to 0.38 LogRAD). Adverse events included macular hole persistence in 1 case and macular edema in 3 cases.

Conclusions: : No relevant difference between BB and ICG was detected for eyes with macular hole. For eyes with macular pucker BB was inferior to ICG in this study. The results justify a larger clinical trial.

Clinical Trial: : http://www.clinicaltrials.gov NCT 01083004

Keywords: macular holes • vitreoretinal surgery • retina 
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