March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Wavefront profile of Ectasia Susceptible Corneas
Author Affiliations & Notes
  • Alain Saad
    Cataract & Refractive Surgery, Rothschild Foundation, Paris, France
  • Damien Gatinel
    Cataract & Refractive Surgery, Rothschild Foundation, Paris, France
  • Footnotes
    Commercial Relationships  Alain Saad, None; Damien Gatinel, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4030. doi:
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      Alain Saad, Damien Gatinel; Wavefront profile of Ectasia Susceptible Corneas. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4030.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas.

Methods: : We retrospectively reviewed the data of 220 eyes separated into 3 groups by the Nidek Corneal Navigator System automated corneal classification software: normal (N) (n=123), Forme Fruste Keratoconus (N Topography with contralateral KC) (FFKC) (n=34) and KC (n=63). Anterior corneal and ocular aberrations were obtained with the OPD Scan and compared using a Kruskall Wallis test. Evaluation of these data to discriminate between the three groups was assessed using a Receiver-Operating Characteristic (ROC) curve analysis.

Results: : Corneal and Ocular tilt, vertical coma and trefoil were significantly different in the FFKC as compared to the N group however their clinical relevance was small. The association of individual Zernike coefficients in a discriminant function differentiates between FFKC and normal corneas with a sensitivity of 91% and a specificity of 94%. The discriminant functions between the FFKC and the N group and between the KC and the N group reached an Area under the ROC curve of 0.98 and 0.96 respectively.

Conclusions: : Indices generated from corneal and ocular wavefront can identify very mild forms of ectasia that may be undetected by a Placido-based neural network programs.

Keywords: refractive surgery: corneal topography • refractive surgery • refractive surgery: LASIK 

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