March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Wide Field Angiography in Diagnosis and Management of Familial Exudative Vitreoretinopathy (FEVR)
Author Affiliations & Notes
  • Michael T. Trese
    Associated Retinal Consultants, Royal Oak, Michigan
  • Amir H. Kashani
    Ophthalmology, Associated Retinal Consultants, William Beaumont Hospital, Michigan
  • Antonio Capone, Jr.
    Associated Retinal Consultants, Royal Oak, Michigan
  • Kimberly A. Drenser
    William Beaumont Hospital,
    Associated Retinal Consultants, Royal Oak, Michigan
  • Footnotes
    Commercial Relationships  Michael T. Trese, None; Amir H. Kashani, None; Antonio Capone, Jr., None; Kimberly A. Drenser, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4161. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Michael T. Trese, Amir H. Kashani, Antonio Capone, Jr., Kimberly A. Drenser; Wide Field Angiography in Diagnosis and Management of Familial Exudative Vitreoretinopathy (FEVR). Invest. Ophthalmol. Vis. Sci. 2012;53(14):4161.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

To explore the role of wide-field imaging and angiography in the diagnosis and management of FEVR


Retrospective review of patient records (July 2011 to December 2011) with diagnosis of FEVR at a single, multi-physician, subspeciality, pediatric retina practice. Only patients with clinical examination and wide-field imaging and angiography results were included in this study.


Fourteen patients (24 eyes) with clinical diagnosis of FEVR (stages ranging from 1-5) underwent wide-field imaging and angiography (Optos Inc). The patient population was 28% male. Average age was 23 (range 1-60 years old). Average LogMAR visual acuity in 24 eyes was 0.31 (20/41 Snellen) and ranged from 0 to no light perception (NLP). Two eyes with prosthesis and four others that were NLP were excluded from the study. Here we report a number of distinguishing peripheral vascular patterns not easily observed with standard clinical examination or fundus photography. These include variably avascular areas in the periphery (Figure 1A), small areas of bulbous-like vascular changes (Figure 1A), capillary staining and leakage (Figure 1A), and neovascularization (Figure 1B). Wide-field imaging also reveals exquisite details in patients with subretinal exudation (Figure 1B), macular dragging (Figure 1B), exudative and tractional retinal detachment (Figure 1B).


The most disturbing feature of FEVR is that it shows the potential for unpredictable, lifelong reactivation from any stage. Reactivation is often heralded by leakage and staining of capillaries that are not easily observed on clinical exam or standard fundus photography. The use of serial wide-field angiography is very helpful for diagnosis early disease (stage 1) and equally helpful for close management of more advanced disease (stage 2) which may require image guided laser therapy.  

Keywords: imaging/image analysis: clinical • retinal neovascularization • retina 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.