March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Visual Acuity in Patients with Non-Infectious Uveitis: Outcome Over Time and Risk Factors
Author Affiliations & Notes
  • Maxwell Pistilli
    Ophthalmology, Ophthalmology,
    Univ of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  • Marshall M. Joffe
    Biostatistics & Epidemiology, Uveitis Clinic/Portland VAMC,
    Univ of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  • Douglas A. Jabs
    Ophthalmology, Mount Sinai School of Medicine, New York, New York
  • Grace A. Levy-Clarke
    St Lukes Cataract and Laser Institute, St Petersburg, Florida
  • Robert B. Nussenblatt
    National Eye Inst/NIH, Bethesda, Maryland
  • James T. Rosenbaum
    Ophthalmology, Ophthalmology,
    Casey Eye Institute-OHSU, Portland, Oregon
  • Eric B. Suhler
    Biostatistics & Epidemiology, Uveitis Clinic/Portland VAMC,
    Casey Eye Institute-OHSU, Portland, Oregon
  • Jennifer E. Thorne
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • C Stephen Foster
    Ophthalmology, Ocular Immunol & Uveitis Fndtn, Cambridge, Massachusetts
  • John H. Kempen
    Ophthalmology - Biostatistics & Epidemiology,
    Univ of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  Maxwell Pistilli, None; Marshall M. Joffe, None; Douglas A. Jabs, None; Grace A. Levy-Clarke, None; Robert B. Nussenblatt, None; James T. Rosenbaum, None; Eric B. Suhler, None; Jennifer E. Thorne, None; C Stephen Foster, None; John H. Kempen, None
  • Footnotes
    Support  NIH/NEI Grant EY014943, Research to Prevent Blindness, Mackall Foundation, NEI Intramural Funds, Dept of Veterans Affairs
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 4165. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Maxwell Pistilli, Marshall M. Joffe, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, Eric B. Suhler, Jennifer E. Thorne, C Stephen Foster, John H. Kempen; Visual Acuity in Patients with Non-Infectious Uveitis: Outcome Over Time and Risk Factors. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4165.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

To describe associations between visual acuity (VA) and risk factors for reduced VA among patients with non-infectious uveitis, and to describe their VA trajectory over time while under care.


Retrospective cohort study. VA (as logMAR equivalent) and other characteristics of patients with non-infectious uveitis managed at 5 academic ocular inflammation clinics were abstracted via standardized chart reviews. All visits using the same VA testing method as used at the initial visit (with correction or without correction) were binned into baseline, first 3 months, then 6 month intervals to 3 years, and 1 year intervals to 5 years. Visits within 30 days following surgical procedures were excluded. Linear mixed models evaluated the association of demographic and clinical characteristics with VA, and separately using inverse probability of censoring weights to correct for missing follow-up visits, the mean VA over time within different types of uveitis.


On average, eyes with uveitis experienced an improvement (decreased logMAR) in VA acuity over the first 6 months of care; this gain was sustained over five years except in posterior uveitis cases. Particular attention to prevention or reversal of factors associated with lower VA, when feasible, may lead to better visual outcomes. The observation that most types of uveitis tend to improve under tertiary care suggests that change in visual acuity may be a better outcome for clinical studies than the proportion losing visual acuity.

Keywords: visual acuity • clinical (human) or epidemiologic studies: risk factor assessment • uveitis-clinical/animal model 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.