Purchase this article with an account.
Rasmus Ejstrup, Jens F. Kiilgaard, Maria V. Kyhn, Morten D. de la Cour; Effect of Glial cell-line Derived Neurotrophic Factor on retinal function after Branch Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4506.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigat the effect of Glial cell-line Derived Neurotrophic Factor (GDNF) on the multifocal electroretinogram (mfERG) after induced Branch Retinal Vein Occlusion (BRVO) in pigs. Inner retinal function can be meassured with four-frame mfERG and outer retinal function with standard mfERG.
Electrophysiological examination of retinas was performed in 18 pigs with standard and four-frame mfERG four weeks after induced BRVO and intravitreal injection of GDNF or Vehicle. BRVO was induced by intraocular diathermia of the superior retinal vein. The ratio of mfERG amplitudes between experimental and healthy fellow eye was calculated in all animals (BRVO eye/Healthy eye).
GDNF improved the four-frame mfERG responses, as rations were higher in the GDNF group (1.09, CI 0.96-1.24) compared with the vehicle group (0.69, CI 0.45-0.99, p=0.02). This difference between groups was not significant for the standard mfERG; GDNF (0.89, CI 0.73-2.03) and Vehicle (0.68, CI 0.51-4.2, p=0.13).
GDNF improves inner retinal function assesed by four-frame mfERG after induced BRVO in porcine eyes but not outer retinal function assesed by standard mfERG.
This PDF is available to Subscribers Only