April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Effect of Glial cell-line Derived Neurotrophic Factor on retinal function after Branch Retinal Vein Occlusion
Author Affiliations & Notes
  • Rasmus Ejstrup
    Eye Department, Glostrup Hospital, Univ of Copenhagen, Glostrup, Denmark
  • Jens F. Kiilgaard
    Dept of Ophthalmology, Rigshospitalet, Copenhagen, Denmark
  • Maria V. Kyhn
    Department of Ophthalmology, Frederiksberg Copenhagen Univ Hosp, Copenhagen S, Denmark
  • Morten D. de la Cour
    Eye Department, Glostrup Hospital, University of Copenhagen, Charlottenlund, Denmark
  • Footnotes
    Commercial Relationships  Rasmus Ejstrup, None; Jens F. Kiilgaard, None; Maria V. Kyhn, None; Morten D. de la Cour, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4506. doi:
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      Rasmus Ejstrup, Jens F. Kiilgaard, Maria V. Kyhn, Morten D. de la Cour; Effect of Glial cell-line Derived Neurotrophic Factor on retinal function after Branch Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4506.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To investigat the effect of Glial cell-line Derived Neurotrophic Factor (GDNF) on the multifocal electroretinogram (mfERG) after induced Branch Retinal Vein Occlusion (BRVO) in pigs. Inner retinal function can be meassured with four-frame mfERG and outer retinal function with standard mfERG.

Methods: : Electrophysiological examination of retinas was performed in 18 pigs with standard and four-frame mfERG four weeks after induced BRVO and intravitreal injection of GDNF or Vehicle. BRVO was induced by intraocular diathermia of the superior retinal vein. The ratio of mfERG amplitudes between experimental and healthy fellow eye was calculated in all animals (BRVO eye/Healthy eye).

Results: : GDNF improved the four-frame mfERG responses, as rations were higher in the GDNF group (1.09, CI 0.96-1.24) compared with the vehicle group (0.69, CI 0.45-0.99, p=0.02). This difference between groups was not significant for the standard mfERG; GDNF (0.89, CI 0.73-2.03) and Vehicle (0.68, CI 0.51-4.2, p=0.13).

Conclusions: : GDNF improves inner retinal function assesed by four-frame mfERG after induced BRVO in porcine eyes but not outer retinal function assesed by standard mfERG.

Keywords: neuroprotection • vascular occlusion/vascular occlusive disease • electroretinography: non-clinical 

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