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Nana Tachi, Masayuki Ashikari, Tsutomu Yasukawa, Yoshio Hirano, Yuichiro Ogura; The Impact Of Stop-smoking And Antioxidant Supplements On Patients With Chronic Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4511.
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© ARVO (1962-2015); The Authors (2016-present)
Chronic central serous chorioretinopathy (CSC) has persistent serous retinal detachment with indistinct or diffuse leakage on fluorescein angiography, resulting in gradual vision loss. Chronic CSC has pathological features partly similar to polypoidal choroidopathy. The purpose of the current study is to evaluate the impact of stopping smoking and antioxidant supplements on chronic CSC.
Seventeen eyes of 15 patients with diagnosis of chronic CSC were enrolled, involving 12 eyes of 11 men and 5 eyes of 4 women. Averaged age was 55.5 ± 9.6 years. Mean follow-up period was 12.5 months. After diagnosed as chronic CSC, patients were guided so as to stop smoking for current smokers and take vitamin and mineral supplements (Ocuvite® Lutein: Bosch & Lomb; or Sante Lutax® 15: Santen Pharmaceutical Co.) for all patients. Serous retinal detachment (sRD) measured by optical coherence tomography (OCT) and visual acuity was assessed.
Seven patients (46.7%) were current smokers. While all of these patients could stop smoking, only 1 patient could not take supplements. Four patients (26.7%) were experienced smokers, and the other 4 patients (26.7%) nonsmokers. These patients all could take supplements. Of 10 eyes with OCT data at month 1, sRD was completely resolved in 5 eyes (50.0%), reduced in 3 eyes (30.0%), and same as preoperative volume in 2 eyes (20.0%). During the observation period, sRD was totally resolved in 11 of 17 eyes (64.7%) within averaged duration of 4.0 ± 3.1 months. Three eyes (17.6%) reduced sRD partially and the other 3 eyes (17.6%) had no change in sRD. Of 11 eyes with complete resolution of sRD, 3 eyes had recurrence of sRD because of re-start of smoking and/or stop of the take of supplements.
Chronic CSC has been recently reported to be treatable by photodynamic therapy. However, it may be worthwhile for these patients to be observed for a few months with no-smoking and antioxidant supplements.
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