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Andrew A. Kao, Anat Galor, Carol L. Karp, Sander R. Dubovy; Pathologic Characteristics of Ocular Surface Squamous Neoplasm at Bascom Palmer Eye Institute: 2001 - 2010. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4532.
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© ARVO (1962-2015); The Authors (2016-present)
To review the pathologic characteristics, including grade, of ocular surface squamous neoplasms (OSSN) biopsied at Bascom Palmer Eye Institute from 2001 - 2010.
A total of 711 pathology reports containing a diagnosis of "conjunctival intraepithelial neoplasia" and/or "squamous cell carcinoma" from January 1, 2001, to September 20, 2010, from 623 patients, were retrospectively analyzed. Focality of OSSN lesions and pathologic grade were documented.
OSSN lesions were unifocal in 595 specimens (83.7%) and multifocal in 116 specimens (16.3%). Two-hundred and forty lesions (33.8%) were diagnosed as conjunctival intraepithelial neoplasia, with 60 of these lesions (8.4%) graded as mild, 111 lesions (15.6%) graded as moderate, and 69 lesions (9.7%) graded as severe. Carcinoma-in-situ was present in 360 lesions (50.6%), and squamous cell carcinoma was present in 89 lesions (12.5%). Pathologic grade could not be determined in 22 lesions (3.1%) due to inadequate material, fragmented tissue, or tangential sectioning.
In our experience, a majority of OSSN cases were unifocal, with approximately 12% of cases graded as invasive squamous cell carcinoma. Careful orientation and processing of biopsied tissue are important for making a pathologic diagnosis.
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