April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Mohs Micrographic Tumor Excision Of Malignant Periorbital Tumors
Author Affiliations & Notes
  • Christian K. Vorwerk
    Dept of Ophthalmology,
    Otto von Guericke University, Magdeburg, Germany
  • Henrike Jostmeyer
    Dept of Ophthalmology,
    Otto von Guericke University, Magdeburg, Germany
  • Doerthe Kuester
    Dept of Pathology,
    Otto von Guericke University, Magdeburg, Germany
  • Wolfgang Behrens-Baumann
    Dept of Ophthalmology,
    Otto von Guericke University, Magdeburg, Germany
  • Footnotes
    Commercial Relationships  Christian K. Vorwerk, None; Henrike Jostmeyer, None; Doerthe Kuester, None; Wolfgang Behrens-Baumann, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4536. doi:
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      Christian K. Vorwerk, Henrike Jostmeyer, Doerthe Kuester, Wolfgang Behrens-Baumann; Mohs Micrographic Tumor Excision Of Malignant Periorbital Tumors. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4536.

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      © ARVO (1962-2015); The Authors (2016-present)

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In times of increasing incidence of malignant periorbital neoplasies the demand for optimal surgical care increases as well. Especially when it comes to the very rarely metastasizing basal cell carcinoma, complete micrographic tumor excision (Mohs procedure) in three dimensions is necessary for successful therapy.


The main outcome measures for recurrence are location, prior manifestation of periorbital malignancies, defect size and histological subtype among other criteria. We retrospectively reviewed 183 cases of periorbital malignancies treated by Mohs micrographic surgery (MMS) and plastic reconstruction who presented to the Departement of Ophthalmology, University of Magdeburg between 1995 and 2005.


Of the periorbital malignancies included in the study, 31,7% were already treated in another institution at the time they presented to our clinic. Of the total 183 performed Mohs micrographic surgeries, 170 were basal cell carcinomas. The most common histological subtypes were nodular (70,6%), combined nodular and superficial (20%) and sclerodermiform (5,3%). Three patients had recurrent basal-cell carcinomas (1,64%).


Based on the literature and our own study, MMS provides the lowest recurrence rates. It is also a known, that 3D histology allows tumor excision with a minimal postoperative defect size, due to minimal loss of normal tissue. In summary, MMS is about to become the gold-standard method of treating periorbital malignancies especially in common basal cell carcinomas.

Keywords: tumors • pathology techniques • wound healing 

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