Purchase this article with an account.
Bin Li, Liang Li, zhe zhang, Fei Gao, Jost B. Jonas, Liaoqing Li; E-Cadherin and β-Catenin Expression in Sebaceous Eyelid Adenocarcinomas. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4537.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Since the E-cadherin-catenin complex may be of importance in the cancerogenesis of epithelial tumors, we examined the expression of E-cadherin and β-catenin and in sebaceous adenocarcinomas of the eyelid and correlated the results with clinicopathological parameters.
The study included histological specimen of 32 patients with sebaceous adenocarcinomas of the eyelid. The expression of E-cadherin, β-catenin and Ki-67 nuclear antigen was measured by immunohistochemistry.
The membranous expression of E-cadherin and of β-catenin was reduced in 17 (53%) patients and 18 (56%) patients, respectively, while elevated cytoplasmic levels and a nuclear accumulation of β-catenin were found in 27 (84%) and 6 (19%) patients, respectively. The expression of membranous β-catenin was inversely correlated with the degree of tumor infiltration (P=0.02) and inflammation (P=0.01), and directly correlated with the degree of tumor differentiation (P<0.001). Correspondingly, a low membranous E-cadherin expression in tumors was significantly associated with poor tumor differentiation (P=0.001) and high tumor cell proliferation rate (P=0.004). The membranous E-cadherin expression and the membranous β-catenin expression were significantly associated with each other (Fisher exact probability test, P=0.03).
A decrease in the E-cadherin and β-catenin expression is associated with poor tumor differentiation and increased inflammation, pointing at a potential role of a low E-cadherin and low β-catenin expression for poor prognosis of sebaceous eyelid adenocarcinomas. The findings suggest that the immunohistochemical detection of a low E-cadherin and low β-catenin expression may help in the examination and staging of sebaceous eyelid adenocarcinomas.
This PDF is available to Subscribers Only