Abstract
Purpose: :
Choroidal osteoma is a benign intraocular tumor composed of mature bone that replaces the full thickness of the choroid. The detail architecture of the osteoma in the choroid has not been clearly understood because choroidal pigmented tissue sometimes overlies and interferes visibility of the tumor. The purpose of this study was to observe the deep choroid with osteoma in vivo by using high-penetration optical coherence tomography (HP-OCT).
Methods: :
Three eyes with choroidal osteoma were observed with prototype HP-OCT using 1060 nm wavelength light source (Axial resolution 11 microns, and scan speed 50,000 A-scans/sec), allowing us to observe the deep choroid and even sclera, better than commercially available OCT using 840 nm wavelength light source. Retinal and choroidal vascular changes were also evaluated with fluorescein and indocyanine green angiogram.
Results: :
Choroidal osteoma, was typically recognized as creamy-white lesion at the central part and orange at the periphery by indirect ophthalmoscopy. HP-OCT examination showed that choroidal osteoma in a marginal legion replaces about the two thirds of the full thickness choroid and a thinned choroidal tissue was observed beneath choroidal osteoma. The blood vessels were also observed inside the tumor. The blood vessels were observed in the thinned choroid with angiography, which was corresponded with HP-OCT. The depth, thickness and the extension of osteoma was able to be clearly identified with HP-OCT in all cases.
Conclusions: :
Significant choroidal structural changes underlies in choroidal osteoma. More precise location of choroidal osteoma can be disclosed by HP-OCT, which was sometimes difficult with conventional systems.
Keywords: choroid • tumors • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)