Purchase this article with an account.
Ireneusz Majsterek, Lukasz Markiewicz, Karolina Przybylowska, Anna K. Kurowska, Jerzy Szaflik, Jacek P. Szaflik; An Association Of The MMP1 –1607 1G/2G And The TIMP1 372 T/C Gene Polymorphisms With A Risk Of Primary Open Angle Glaucoma In A Polish Population. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4602.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Primary open angle glaucoma (POAG) is considered as a main cause of irreversible blindness worldwide. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) have been extensively studied as a POAG risk factors. Recently, several single nucleotide polymorphisms (SNPs) for MMPs and TIMPs encoding genes have been reported in POAG patients.
In the present study we examined group of 552 unrelated Caucasian subjects consist of 199 POAG patients (68 male and 131 female; mean age 70±14) and 253 controls (72 male and 181 female; mean age 67±18). The MMP1 –1607 1G/2G and TIMP1 372 T/C gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
A statistically significant increase of the 2G/2G genotype (OR 1.74; 95% CI 1.06-2.85; p = 0.018) as well as 2G allele frequency (OR 1.34; 95% CI 1.03-1.75; p = 0.016) of MMP1 in POAG patients in comparison to healthy controls were estimated. There were not differences of the genotype and allele distributions and odds ratios of the TIMP1 T/C polymorphism between patients and controls group. We also did not find any link of TIMP1 with MMP1 gene-gene interaction and a risk of POAG occurrence.
In conclusion, we suggest that the –1607 1G/2G polymorphism of MMP1 gene may be considered as an important risk factor associated with primary open angle glaucoma in a Polish population.
This PDF is available to Subscribers Only