April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Developmental Abnormality Of Schlemm's Canal In Primary Open Angle Glaucoma
Author Affiliations & Notes
  • Teruhiko Hamanaka
    Ophthalmology, Japanese Red Cross Medical Ctr, Shibuya-Ku, Japan
  • Akira Matsuda
    Ophthalmology, Juntendo University, Tokyo, Japan
  • Nobuo Ishida
    Ophthalmology, Ishida Eye Clinic, Joetsu, Japan
  • Takuro Fujimaki
    Ophthalmology, Juntendo University, Tokyo, Japan
  • Akira Murakami
    Ophthalmology, Juntendo University, Tokyo, Japan
  • Footnotes
    Commercial Relationships  Teruhiko Hamanaka, None; Akira Matsuda, None; Nobuo Ishida, None; Takuro Fujimaki, None; Akira Murakami, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 4668. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Teruhiko Hamanaka, Akira Matsuda, Nobuo Ishida, Takuro Fujimaki, Akira Murakami; Developmental Abnormality Of Schlemm's Canal In Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4668.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

To compare the clinical findings and morphological differences of Schemm’s canal (SC) in trabeculectomy (TLE) specimens of eyes with primary open angle glaucoma (POAG, IOP >21mmHg) between patients with a family history (group A) and those without a family history of POAG (IOP >21mmHg) or ocular hypertension (OH) (group B).


Thirty patients in each group were questioned about the family history of glaucoma in the routine post-operative examination and retrospectively reviewed for age at TLE, visual field (Aurhorn-Greve cassfication), cup/disc ratio, maximum pre-operative IOP, and spherical equivalent power. All affected family members with glaucoma in group A were examined for whether they had normal tension glaucoma, angle closure glaucoma, pseudoexfoliation or other types of secondary glaucoma. Patients who have other than POAG (IOP >21mmHg) or OH in the family history were excluded from this study. Seventy-four TLE specimens (40 eyes in group A, and 34 eyes in group B) of 30 patients in each group were embedded in paraffin and processed for immunohistochemical staining of thrombomodulin to detect the endothelium of SC, and the meridional length of SC was measured.


Maximum pre-operative IOP, spherical equivalent power and the length of SC showed a significant difference between the two groups (Table). The thrombomodulin staining pattern of SC in most of the eyes in group A tended to be very strong and was similar to that of Sondermann’s canal.


Higher myopia and IOP in the eyes of group A suggested that POAG may have occurred at a younger age. The developmental abnormality of SC may be very important for causing POAG in hereditary POAG.  

Keywords: outflow: trabecular meshwork • development • pathology: human 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.