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Roberto Dellape, Jr., Ana C. Fortes, Amaryllis Avakian, Newton Kara Jose, Valerio H. Santos, Pedro C. Carricondo; Prospective Comparison Of Pupil Dilatation For Cataract Surgery Using Tropicamide Associated To Phenylephrine, Cyclopentolate, Ketorolac Tromethamine Or Saline Solution. Invest. Ophthalmol. Vis. Sci. 2011;52(14):4709.
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To compare the pupil dilatation in pre and perioperative period for cataract surgery, using tropicamide associated to one of the following drugs: phenylephrine, cyclopentolate, ketorolac or saline solution (control group).
In this prospective, triple blind, masked study, patients with cataract to be submitted to phacoemulsification were randomly allocated into four groups, all receiving tropicamide and one of the following: Group 1- Ketorolac tromethamine; Group 2 - Cyclopentolate; Group 3 - Phenylephrine 10% and Group 4 - Saline solution 0.9%. The pupil was measured before starting the eye drops, immediately before the surgery and at the end of the surgery.
Ninety eight eyes of patients with cataract were randomized to one of the four groups for pupil dilatation. Before starting the eye drops, were realized a random allocation of the volunteers that signed the informed consent. There was no statistical difference (p>0,05) in the initial measure of pupil diameter between the groups. The patients were not differentiated by the iris color or eye (right or left) for allocation. These variables showed no differences in post test analysis of pupil dilatation. There were no statistical differences in the preoperative measurement, although the group using phenylephrine had a higher pupil diameter at this moment (6,77mm). In postoperative measurement,the group using ketorolac trometamine showed no difference to control group, using saline solution. The groups using phenylephrine and cyclopentolate had statistically higher pupil diameter in the postoperative measurement. There was no difference between these two groups.
The higher mean pupil diameter before the surgery was achieved with the use of tropicamide and phenylephrine, altough there is no statistical differences to other groups. At the end of the surgery, the higher mean pupil diameter was observed in the groups using phenylephrine or cyclopentolate.
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